Ulcerative_Colitis_Lymphocyte

Pathway ID: SIGNOR-ULCERATIVE_COLITIS_LYMPHOCYTE

Description: In Ulcerative Colitis, IL-4 production in lymphocytes is increased by the transcription factor GATA-3, which also blocks IL-12 production and, consequently, TH1 polarization. TH2 lymphocytes produce three types of cytokines: IL-4, IL-5, and IL-13, which perpetuate inflammation.

Curated by: Tiberia

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24 Seed Entities

Organism:
Name Primary ID
STAT6 P42226
IL10 P22301
IL4 P05112
FOXP3 Q9BZS1
JAK1/STAT1/STAT3 SIGNOR-C120
GATA3 P23771
IL5 P05113
Proliferation SIGNOR-PH4
IL4R P24394
Immune_response SIGNOR-PH17
T-lymphocyte_diff SIGNOR-PH112
CD3 SIGNOR-C432
T-reg_differentiation SIGNOR-PH91
TBX21 Q9UL17
9-cis-retinoic acid CHEBI:50648
JAK1 P23458
M2_polarization SIGNOR-PH55
TCR SIGNOR-C153
IL5RA Q01344
ERK1/2 SIGNOR-PF1
STAT5A P42229
JAK2 O60674
AP1 SIGNOR-C154
LCK P06239