| + |
PARP1 | down-regulates quantity by repression 
transcriptional regulation
|
THBD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254893 |
|
|
Homo sapiens |
Squamous Cell Carcinoma Cell |
| pmid |
sentence |
| 21489980 |
Silencing of PARP1 resulted in a strong down-regulation of TM expression in Met-5A cells, while restoring TM expression in H28 cells. We propose that methylation of the TM promoter is responsible for silencing of TM expression in MM tissue, a process that is regulated by PARP1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PARP1 | up-regulates quantity by expression 
transcriptional regulation
|
THBD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254892 |
|
|
Homo sapiens |
Mesothelioma Cell |
| pmid |
sentence |
| 21489980 |
Silencing of PARP1 resulted in a strong down-regulation of TM expression in Met-5A cells, while restoring TM expression in H28 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBP/p300 | up-regulates quantity by expression
transcriptional regulation
|
THBD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253908 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15677570 |
We further show evidence suggesting that NF-κB inhibits TM expression indirectly by competition for the coactivator p300/CBP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF2 | up-regulates quantity by expression
transcriptional regulation
|
THBD |
0.442 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254543 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19661484 |
Thrombomodulin upregulation was independent of NF-kappaB signaling, a principal target of proteasome inhibitors, but was instead a direct consequence of increased expression of the Krüppel-like transcription factors, KLF2 and KLF4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
THBD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255216 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22406829 |
In carcinomas the expression of thrombomodulin (TM) is inversely correlated with tumour progression and metastasis. The expression of TM is negatively regulated by NF-?B- and GSK3-?-dependent signalling pathways and positively regulated by retinoic acid and transcription factor Sp1 in PrEC, LNCaP and PC-3 cells, but not in DU-145 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF4 | up-regulates activity
transcriptional regulation
|
THBD |
0.307 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254546 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19661484 |
Thrombomodulin upregulation was independent of NF-kappaB signaling, a principal target of proteasome inhibitors, but was instead a direct consequence of increased expression of the Krüppel-like transcription factors, KLF2 and KLF4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | down-regulates quantity by repression
transcriptional regulation
|
THBD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253909 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15677570 |
We further show evidence suggesting that NF-κB inhibits TM expression indirectly by competition for the coactivator p300/CBP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
THBD | form complex 
binding
|
Thrombin-Thrombomodulin |
0.903 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267726 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29880919 |
Thrombin also activates the negative regulators of the cascade, after complexing with thrombomodulin (TM) and endothelial protein C receptor (EPCR), to activate protein C (PC) to activated PC (APC). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Plasma |
| + |
NFKB1 | down-regulates quantity by repression
transcriptional regulation
|
THBD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254811 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17211835 |
Blocking the transcriptional activation of NF-kappaB prevented the TNFalpha-induced downregulation of TM. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
all-trans-retinoic acid | up-regulates quantity by expression
|
THBD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255217 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22406829 |
In carcinomas the expression of thrombomodulin (TM) is inversely correlated with tumour progression and metastasis. The expression of TM is negatively regulated by NF-?B- and GSK3-?-dependent signalling pathways and positively regulated by retinoic acid and transcription factor Sp1 in PrEC, LNCaP and PC-3 cells, but not in DU-145 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
THBD
- 
- 