Summary

Name CD28
Full Name T-cell-specific surface glycoprotein CD28
Synonyms TP44
Primary ID P10747
Links - -
Type protein
Relations 13
Pathways T cell activation
Function Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CD28 0.57
Publications: 2 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation CD28 0.2
Publications: 3
+ up-regulates img/direct-activation.png phosphorylation CD28 0.2
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRB2 0.46
Publications: 2 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png binding PIK3CG 0.14
Publications: 1 Organism: Homo Sapiens