T cell activation

Pathway ID: SIGNOR-TCAView in NDEx

Description: (From Wikipedia) T cells utilise the Src family kinases in transmembrane signalling largely to phosphorylate tyrosines that are part of immunoreceptor tyrosine-based activation motifs (ITAM) in intracellular parts of CD3 and ζ chains. Early signaling steps implicate the kinases lck an Fyn and Zap70 and the phosphatase CD45 after TCR triggering: When a T-cell receptor is activated by contact with a peptide:MHC complex, CD45 dephosphorylates inhibitory tyrosine of membrane-localized Src family kinases Fyn and Lck, previously recruited and activated by CD4 or CD8 coreceptors. Activated Fyn and Lck phosphorylates ITAMs on the CD3 and ζ chains. This allows cytoplasmic kinases of the Syk family (ZAP-70) to bind to the ITAM and activated ZAP-70 phosphorylates tyrosines on the adaptor protein LAT, which then attracts PLC-γ.

Curated by: Gianni

42 Seed Entities

Organism:
Name Primary ID
CALM1 P0DP23
CTTN Q14247
CD28 P10747
GRB2 P62993
T_cell_activation SIGNOR-PH73
ARP2/3 SIGNOR-C146
F-actin_assembly SIGNOR-PH18
LCP2 Q13094
PI3K SIGNOR-C156
NCK1 P16333
NFKBIA P25963
TCR SIGNOR-C153
IKK-complex SIGNOR-C14
BRAF P15056
NfKb-p65/p50 SIGNOR-C13
CSK P41240
Immune_response SIGNOR-PH17
calcium(2+) CHEBI:29108
CD4 P01730
PLCG1 P19174
ZAP70 P43403
ERK1/2 SIGNOR-PF1
SOS1 Q07889
AKT SIGNOR-PF24
1,2-diacyl-sn-glycerol CHEBI:17815
PRKCA P17252
MEK1/2 SIGNOR-PF25
LAT O43561
PTPRC P08575
Class II MHC:Antigen SIGNOR-C429
CD3 SIGNOR-C432
PDPK1 O15530
NFATC1 O95644
Calcineurin SIGNOR-C155
LCK P06239
PIP3 CHEBI:16618
FYN P06241
AP1 SIGNOR-C154
CD8A P01732
PAK1 Q13153
HRAS P01112
Class I MHC:Antigen SIGNOR-C426