Relation Results

Summary

Name SLC2A1
Full Name Solute carrier family 2, facilitated glucose transporter member 1
Synonyms Glucose transporter type 1, erythrocyte/brain, GLUT-1, HepG2 glucose transporter | GLUT1
Primary ID P11166
Links - -
Type protein
Relations 13
Pathways Glycolysis and Gluconeogenesis
Function Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:18245775, PubMed:19449892, PubMed:25982116, Pu ...
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Type: Score: Layout: SPV 
0.20.3640.4140.80.5960.3610.4330.3020.5520.5310.80.26AKTSLC2A14.1 complexHIF-1 complexα-D-glucoseTP53SP1MYCAnkyrin complexAKT1STOMglucoseYAP1

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Relations
Regulator
Mechanism
target
score ℹ
+ AKTup-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC2A1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-45064 Homo sapiens
pmid sentence
The constitutively active akt also increased the synthesis of the ubiquitously expressed glucose transporter 1. The increased glucose influx in the 3t3-l1 adipocytes directed lipid but not glycogen synthesis
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ SLC2A1form complex img/form-complex.png binding 4.1 complex 0.364
Identifier Residue Sequence Organism Cell Line
SIGNOR-266038 Homo sapiens Erythrocyte
pmid sentence
The cytoskeleton plays a key role in maintaining the morphology and function of erythrocyte membranes. Many proteins, such as ankyrin, spectrin alpha- and beta-chains, proteins 4.1, or 4.1R and actin, cover the inner surface of the erythrocyte membrane to form two protein complexes, the ankyrin and protein 4.1 complex| the latter consists of Band 3 dimers binding Adducins alpha and beta, Glycophorin C, GLUT1 and Stomatin [15, 16]
Publications: 1 Organism: Homo Sapiens
+ HIF-1 complexup-regulates quantity img/direct-activation.png transcriptional regulation SLC2A1 0.414
Identifier Residue Sequence Organism Cell Line
SIGNOR-267478 Rattus norvegicus
pmid sentence
Collectively these results indicate that H-Ras up-regulates the glut1 promoter, at least in part, by increasing HIF-1alpha protein levels leading to transactivation of promoter through the HIF-1 binding site.
Publications: 1 Organism: Rattus Norvegicus
Pathways:Glycolysis and Gluconeogenesis
+ SLC2A1up-regulates quantity img/direct-activation.png relocalization α-D-glucose 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267458 Homo sapiens
pmid sentence
GLUT1 plays a critical role in cerebral glucose uptake as the major GLUT isoform expressed in brain endothelial cells.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ TP53down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SLC2A1 0.596
Identifier Residue Sequence Organism Cell Line
SIGNOR-267464 Homo sapiens
pmid sentence
P53 regulates basal expression of AIF and SCO2 and facilitates oxidative phosphorylation. The expression of GLUT1, GLUT4, and HK2 is negatively regulated by p53, whereas TIGAR expression is induced by p53. The net result of p53-mediated regulation of these glycolytic enzymes is the suppression of glycolysis. In addition, p53 directly binds and inhibits G6PD activity and downregulates the pentose phosphate pathway.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ SP1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC2A1 0.361
Identifier Residue Sequence Organism Cell Line
SIGNOR-241485 Mus musculus
pmid sentence
These data suggest a regulatory model in which MyoD activation during myogenesis causes the down-regulation of Sp1, which contributes to the repression of GLUT1 gene transcription and, therefore, leads to the reduction in GLUT1 expression and glucose transport.
Publications: 1 Organism: Mus Musculus
+ MYCup-regulates quantity img/direct-activation.png transcriptional regulation SLC2A1 0.433
Identifier Residue Sequence Organism Cell Line
SIGNOR-259987 Rattus norvegicus
pmid sentence
C-Myc directly transactivates genes encoding GLUT1, phosphofructokinase, and enolase and increases glucose uptake in Rat1 fibroblasts. Nuclear run-on studies confirmed that the GLUT1 transcriptional rate is elevated by c-Myc. Our findings suggest that overexpression of the c-Myc oncoprotein deregulates glycolysis through the activation of several components of the glucose metabolic pathway.
Publications: 1 Organism: Rattus Norvegicus
+ SLC2A1form complex img/form-complex.png binding Ankyrin complex 0.302
Identifier Residue Sequence Organism Cell Line
SIGNOR-266017 Homo sapiens Erythrocyte
pmid sentence
The ankyrin associated complex brings together proteins of both the band 3 tetrameric complex (band 3, glycophorin A (GPA), protein 4.2, carbonic anhydrase II) and the Rh complex (RhAG, RhCE, RhD, CD47, ICAM-4, glycophorin B (GPB)) 
Publications: 1 Organism: Homo Sapiens
+ AKT1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC2A1 0.552
Identifier Residue Sequence Organism Cell Line
SIGNOR-252579 Homo sapiens
pmid sentence
The constitutively active akt also increased the synthesis of the ubiquitously expressed glucose transporter 1. The increased glucose influx in the 3t3-l1 adipocytes directed lipid but not glycogen synthesis
Publications: 1 Organism: Homo Sapiens
+ STOMdown-regulates activity img/direct_inhibition.png binding SLC2A1 0.531
Identifier Residue Sequence Organism Cell Line
SIGNOR-261278 Homo sapiens
pmid sentence
Similar to the results obtained in the RBC, Glut1 and stomatin immunoprecipitated with each other in lysates of Clone 9 cells. The above results suggest that stomatin is closely associated with Glut1 in the plasma membrane and that overexpression of stomatin results in a depression in the basal rate of glucose transport.
Publications: 1 Organism: Homo Sapiens
+ HIF-1 complexup-regulates quantity by expression img/direct-activation.png transcriptional regulation SLC2A1 0.414
Identifier Residue Sequence Organism Cell Line
SIGNOR-267450 Homo sapiens
pmid sentence
HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ SLC2A1up-regulates quantity img/direct-activation.png relocalization glucose 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267460 Homo sapiens
pmid sentence
GLUT1 plays a critical role in cerebral glucose uptake as the major GLUT isoform expressed in brain endothelial cells.
Publications: 1 Organism: Homo Sapiens
+ YAP1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC2A1 0.26
Identifier Residue Sequence Organism Cell Line
SIGNOR-276584
pmid sentence
Transcriptomic and metabolomic analyses reveal that Yap regulates expression of glucose transporter glut1, causing decreased glucose uptake and use for nucleotide biosynthesis in yap-/- mutants, and impaired glucose tolerance in adults.
Publications: 1
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