| + |
DPF2 | down-regulates activity 
binding
|
ESRRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-239539 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 25713408 |
DPF2 directly bound to ERRalpha and suppressed the transactivation function of nuclear receptors such as androgen receptor. DPF2 was recruited to ERR target gene promoters in myoblast cells, and knockdown of DPF2 derepressed the level of mRNA expressed by target genes of ERRalpha. These results show that DPF2 acts as a nuclear receptor-selective co-repressor for ERRalpha by associating with both acetylated histone H3 and HDAC1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ESRRA | down-regulates quantity by repression 
transcriptional regulation
|
NR2F1 |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253795 |
|
|
Homo sapiens |
Bronchoalveolar Lavage |
| pmid |
sentence |
| 15955695 |
In cancer tissue, the expression levels of EAR-2, COUP-TF1, EARgamma, Snail, and Slug decrease, and aromatase expression is then up-regulated through the binding of ERRalpha to S1 and the binding of CREB1 or related factors to CREaro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates activity 
|
ESRRA |
0.919 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253392 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18074631 |
The PGC1 transcriptional coactivators are major regulators of several crucial aspects of energy metabolism. PGC1alpha controls many aspects of oxidative metabolism, including mitochondrial biogenesis and respiration through the coactivation of many nuclear receptors, and factors outside the nuclear receptor family. ERRalpha, NRF1 and NRF2 are key targets of the PGC1s in mitochondrial biogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ESRRA | up-regulates quantity by expression 
transcriptional regulation
|
RNF208 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269052 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 31862882 |
Furthermore, RNF208 was induced by 17β-estradiol (E2) treatment in an estrogen receptor alpha (ΕRα)-dependent manner |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESRRA | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 |
0.257 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253790 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15955695 |
In cancer tissue, the expression levels of EAR-2, COUP-TF1, EARgamma, Snail, and Slug decrease, and aromatase expression is then up-regulated through the binding of ERRalpha to S1 and the binding of CREB1 or related factors to CREaro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESRRA | down-regulates quantity by repression
transcriptional regulation
|
NR2F6 |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253796 |
|
|
Homo sapiens |
Brown Adipose Tissue |
| pmid |
sentence |
| 15955695 |
In cancer tissue, the expression levels of EAR-2, COUP-TF1, EARgamma, Snail, and Slug decrease, and aromatase expression is then up-regulated through the binding of ERRalpha to S1 and the binding of CREB1 or related factors to CREaro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESRRA | up-regulates quantity by expression
transcriptional regulation
|
CYP19A1 |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253794 |
|
|
Homo sapiens |
BRL-3A Cell |
| pmid |
sentence |
| 15955695 |
In cancer tissue, the expression levels of EAR-2, COUP-TF1, EARgamma, Snail, and Slug decrease, and aromatase expression is then up-regulated through the binding of ERRalpha to S1 and the binding of CREB1 or related factors to CREaro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESRRA | down-regulates quantity by repression
transcriptional regulation
|
SNAI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253799 |
|
|
Homo sapiens |
Bulb |
| pmid |
sentence |
| 15955695 |
In cancer tissue, the expression levels of EAR-2, COUP-TF1, EARgamma, Snail, and Slug decrease, and aromatase expression is then up-regulated through the binding of ERRalpha to S1 and the binding of CREB1 or related factors to CREaro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ESRRA
- 
- 