| + |
APC-c | down-regulates quantity by destabilization 
polyubiquitination
|
SKIL |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272622 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11741538 |
We demonstrate that the anaphase-promoting complex (APC) is a ubiquitin ligase required for the destruction of SnoN and that the APC pathway is regulated by TGF-beta. The destruction box of SnoN is required for its degradation in response to TGF-beta signaling. Furthermore, the APC activator CDH1 and Smad3 synergistically regulate SnoN degradation. Under these circumstances, CDH1 forms a quaternary complex with SnoN, Smad3, and APC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SKIL | down-regulates
binding
|
SMAD1/4 |
0.679 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217703 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12419246 |
Ski also represses bmp signaling through interactions with smad4 and bmp-specific r-smads, smad1 or smad7 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217709 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Ski also represses bmp signaling through interactions with smad4 and bmp-specific r-smads, smad1 or smad7 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SKIL | down-regulates activity
binding
|
SMAD4 |
0.889 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236152 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12793438 |
The ski and snon protein family associate with and repress the activity of smad2, smad3, and smad4, three members of the tgf-fl signaling pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71633 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10531062 |
Thus, SnoN can interact with Smad4 and Smad2 and inhibit their abilities to activate transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SKIL | down-regulates
binding
|
SMAD5 |
0.438 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95474 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12419246 |
Ski also represses bmp signaling through interactions with smad4 and bmp-specific r-smads, smad1 or smad8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SKIL | down-regulates activity
binding
|
SMAD3/SMAD4 |
0.848 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253303 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 12793438 |
The ski and snon protein family associate with and repress the activity of smad2, smad3, and smad4, three members of the tgf-fl signaling pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SKIL | down-regulates activity
binding
|
SMAD2 |
0.81 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236099 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12793438 |
The ski and snon protein family associate with and repress the activity of smad2, smad3, and smad4, three members of the tgf-fl signaling pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227479 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10531062 |
Thus, SnoN can interact with Smad4 and Smad2 and inhibit their abilities to activate transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
FZR1 | down-regulates quantity by destabilization
binding
|
SKIL |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272621 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11741538 |
We demonstrate that the anaphase-promoting complex (APC) is a ubiquitin ligase required for the destruction of SnoN and that the APC pathway is regulated by TGF-beta. The destruction box of SnoN is required for its degradation in response to TGF-beta signaling. Furthermore, the APC activator CDH1 and Smad3 synergistically regulate SnoN degradation. Under these circumstances, CDH1 forms a quaternary complex with SnoN, Smad3, and APC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SKIL | down-regulates activity
binding
|
SMAD2/SMAD4 |
0.85 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253302 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 12793438 |
The ski and snon protein family associate with and repress the activity of smad2, smad3, and smad4, three members of the tgf-fl signaling pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
SKIL | down-regulates
binding
|
SMAD1 |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195636 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12419246 |
Ski also represses bmp signaling through interactions with smad4 and bmp-specific r-smads, smad1 or smad7 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF111 | down-regulates quantity by destabilization
polyubiquitination
|
SKIL |
0.736 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272885 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23530057 |
Upon TGF-β induction, interaction of Arkadia with phosphorylated Smad2 triggers degradation of SnoN, whereas upon arsenic treatment, interaction of Arkadia with poly-SUMO in PML nuclear bodies induces degradation of polysumoylated PML together with RNF4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF | down-regulates activity
ubiquitination
|
SKIL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253262 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11389444 |
Tgf-beta also induces the association of smurf2 with the transcriptional co-repressor snon and we show that smad2 can function to mediate this interaction. This allows smurf2 hect domain to target snon for ubiquitin-mediated degradation by the proteasome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
HEK-293T Cell, Mv1Lu Cell |
| Pathways: | TGF-beta Signaling |
| + |
RNF111 | down-regulates
ubiquitination
|
SKIL |
0.736 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156430 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17591695 |
Arkadia interacts with snon and induces its ubiquitination irrespective of tgf-beta/activin signaling, but snon is efficiently degraded only when it forms a complex with both arkadia and phosphorylated smad2 or smad3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF2 | down-regulates activity
ubiquitination
|
SKIL |
0.75 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236090 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11389444 |
Tgf-beta also induces the association of smurf2 with the transcriptional co-repressor snon and we show that smad2 can function to mediate this interaction. This allows smurf2 hect domain to target snon for ubiquitin-mediated degradation by the proteasome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
HEK-293T Cell, Mv1Lu Cell |
4.0
SKIL
- 
- 