Relation Results

Summary

Name SMAD2/SMAD4
Primary ID SIGNOR-C8
Links CPX-3208
Type complex
Formed by SMAD4, SMAD2
Relations 13
Pathways Hepatocellular Tumor, myCAF signaling in PDAC, Macrophage: Polarization and myogenesis, Multiple sclerosis, Macrophage: TGF beta, Pancreatic ductal adenocarcinoma (PDA), TGF-beta Signaling, TGFb in cancer

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Type: Score: Layout: SPV 
0.6480.8380.5870.7110.5850.5350.7110.5250.7730.70.7SMAD2/SMAD4MYCSKILCDKN2BSMAD2SP1NANOGSMAD4AP1SKIM2_polarizationFibrosis

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Relations
Regulator
Mechanism
target
score ℹ
+ SMAD2/SMAD4down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYC 0.648
Identifier Residue Sequence Organism Cell Line
SIGNOR-256291 Homo sapiens
pmid sentence
To identify this pathway, we analyzed TGF-β-responsive elements in the human c-myc promoter and found that Smad proteins directly bound to an element in the c-myc promoter and suppressed c-myc promoter activity.
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor
+ SKILdown-regulates activity img/direct_inhibition.png binding SMAD2/SMAD4 0.838
Identifier Residue Sequence Organism Cell Line
SIGNOR-253302 Homo sapiens Melanoma Cell
pmid sentence
The ski and snon protein family associate with and repress the activity of smad2, smad3, and smad4, three members of the tgf-fl signaling pathway
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ SMAD2/SMAD4up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN2B 0.587
Identifier Residue Sequence Organism Cell Line
SIGNOR-256287 Homo sapiens
pmid sentence
Our data demonstrate the physical interactions and functional cooperativity of Sp1 with a complex of Smad2, Smad3 and Smad4 in the induction of the p15Ink4B gene. These findings explain the tumor suppressor roles of Smad2 and Smad4 in growth arrest signaling by TGF-β.
Publications: 1 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA), TGF-beta Signaling, TGFb in cancer
+ SMAD2form complex img/form-complex.png binding SMAD2/SMAD4 0.711
Identifier Residue Sequence Organism Cell Line
SIGNOR-235188 Homo sapiens
pmid sentence
the receptor-regulated Smad, such as Smad2, forms a heterocomplex with the co-mediator Smad, Smad4
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), TGF-beta Signaling, TGFb in cancer
+ SMAD2/SMAD4up-regulates activity img/direct-activation.png binding SP1 0.585
Identifier Residue Sequence Organism Cell Line
SIGNOR-256288 Homo sapiens HaCaT Cell
pmid sentence
TGF-β induces the formation and nuclear translocation of a trimeric Smad complex, which in this case is likely to consist of one monomer each of Smad2, Smad3 and Smad4. Smad2 and Smad4 associate directly with Sp1 and co-activate the transcriptional activity of Sp1.
Publications: 1 Organism: Homo Sapiens
+ SMAD2/SMAD4up-regulates quantity by expression img/direct-activation.png transcriptional regulation NANOG 0.535
Identifier Residue Sequence Organism Cell Line
SIGNOR-242049 Homo sapiens Embryonic Stem Cell
pmid sentence
Here, we show that Smad2/3, the downstream effectors of Activin/Nodal signalling, bind and directly control the activity of the Nanog gene in hESCs.
Identifier Residue Sequence Organism Cell Line
SIGNOR-242044 Homo sapiens Esophageal Squamous Cell Carcinoma Cell
pmid sentence
We also find that SMADs bind with the NANOG promoter and that SMAD2/3 activity enhances NANOG promoter activity.
Publications: 2 Organism: Homo Sapiens
+ SMAD4form complex img/form-complex.png binding SMAD2/SMAD4 0.711
Identifier Residue Sequence Organism Cell Line
SIGNOR-235178 Homo sapiens
pmid sentence
the receptor-regulated Smad, such as Smad2, forms a heterocomplex with the co-mediator Smad, Smad4
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), TGF-beta Signaling, TGFb in cancer
+ SMAD2/SMAD4up-regulates activity img/direct-activation.png binding AP1 0.525
Identifier Residue Sequence Organism Cell Line
SIGNOR-256180 Homo sapiens
pmid sentence
The activated TGFβ type I receptor kinase propagates the signal within the cell through phosphorylation of the receptor-regulated (R-)Smad proteins Smad2 and Smad3 at their extreme carboxyl-terminal serine residues.1, 2 The activated R-Smads then form heteromeric complexes with the common-partner (Co-)Smad, Smad4, and accumulate in the nucleus, where they can bind DNA and regulate gene expression. The Smads control gene expression in a cell type-specific manner by interacting with other proteins, such as AP-1, AP-2 and Ets transcription factors and specific co-activators and co-repressors.
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), TGF-beta Signaling, TGFb in cancer
+ SKIdown-regulates activity img/direct_inhibition.png binding SMAD2/SMAD4 0.773
Identifier Residue Sequence Organism Cell Line
SIGNOR-253300 Homo sapiens Melanoma Cell
pmid sentence
The ski and snon protein family associate with and repress the activity of smad2, smad3, and smad4, three members of the tgf-fl signaling pathway
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ SMAD2/SMAD4up-regulates img/indirect-activation.png M2_polarization 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-253588 Homo sapiens
pmid sentence
The SMAD2/3 and PI3K/AKT signaling pathways were crucial for TGF-?-induced SNAIL overexpression in THP-1 cells. These findings suggest that TGF-? skews macrophage polarization towards a M2-like phenotype via SNAIL up-regulation, and blockade of TGF-?/SNAIL signaling restores the production of pro-inflammatory cytokines
Identifier Residue Sequence Organism Cell Line
SIGNOR-249550 Homo sapiens
pmid sentence
Our results establish a novel biological role for TGFbeta signaling in controlling expression of genes characteristic for alternatively activated macrophages. We speculate that lack of TbetaRII signaling reduces the anti-inflammatory M2 phenotype of macrophages because of reduced expression of these products.
Publications: 2 Organism: Homo Sapiens
Pathways:Multiple sclerosis
+ SMAD2/SMAD4up-regulates img/indirect-activation.png Fibrosis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-260440 Homo sapiens
pmid sentence
Smad4 interacted withSmad2/3 and participated in the transcription of downstream pro-fi-brotic target genes
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
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