Summary

Name MYF5
Full Name Myogenic factor 5
Synonyms Myf-5, Class C basic helix-loop-helix protein 2, bHLHc2 | BHLHC2
Primary ID P13349
Links - -
Type protein
Relations 26
Pathways WNT Signaling and Myogenesis
Function Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation MYF5 0.11
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation MYF5 0.17
Publications: 2 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png unknown Proliferation
Publications: 1
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYF5 0.49
Publications: 1
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYF5
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYF5
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYF5 0.24
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYF5 0.13
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Tissue: Muscle, Muscle, Skeletal Muscle, Myotube
+ up-regulates img/indirect-activation.png unknown MYF5 0.34
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/indirect-activation.png unknown MYF5 0.38
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png binding MYF5 0.52
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png unknown MYF5 0.25
Publications: 2 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png unknown MYF5 0.24
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation DES 0.09
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYF5 0.05
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates img/indirect-activation.png unknown Skeletal Muscle Differentiation
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYF5
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates img/indirect-activation.png unknown MYF5 0.12
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYF5 0.49
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Tissue: Muscle, Skeletal Muscle, Skeletal Muscle
+ up-regulates quantity img/indirect-activation.png transcriptional regulation mir-206
Publications: 1 Organism: Mus Musculus
Tissue: Muscle
+ up-regulates quantity img/indirect-activation.png transcriptional regulation MIR1-1
Publications: 1 Organism: Mus Musculus
Tissue: Muscle