| + |
CSNK2A2 | up-regulates activity 
phosphorylation
|
MYF5 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251016 |
Ser133 |
NAIRYIEsLQELLRE |
in vitro |
|
| pmid |
sentence |
| 9461343 |
Here, we report that Myf-5 protein constitutes a substrate for phosphorylation in vitro by protein kinase CK2. We identified two potential phosphorylation sites at serine49 and serine133, both of which seem to be necessary for Myf-5 activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251017 |
Ser49 |
HKAELQGsDEDEHVR |
in vitro |
|
| pmid |
sentence |
| 9461343 |
Here, we report that Myf-5 protein constitutes a substrate for phosphorylation in vitro by protein kinase CK2. We identified two potential phosphorylation sites at serine49 and serine133, both of which seem to be necessary for Myf-5 activity. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
CSNK2A1 | up-regulates activity
phosphorylation
|
MYF5 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250922 |
Ser133 |
NAIRYIEsLQELLRE |
in vitro |
|
| pmid |
sentence |
| 9461343 |
Here, we report that Myf-5 protein constitutes a substrate for phosphorylation in vitro by protein kinase CK2. We identified two potential phosphorylation sites at serine49 and serine133, both of which seem to be necessary for Myf-5 activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250923 |
Ser49 |
HKAELQGsDEDEHVR |
in vitro |
|
| pmid |
sentence |
| 9461343 |
Here, we report that Myf-5 protein constitutes a substrate for phosphorylation in vitro by protein kinase CK2. We identified two potential phosphorylation sites at serine49 and serine133, both of which seem to be necessary for Myf-5 activity. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
PAX3 | up-regulates quantity by expression 
transcriptional regulation
|
MYF5 |
0.487 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200862 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23384562 |
Direct molecular regulation of the myogenic determination gene myf5 by pax3, with modulation by six1/4 factors, is exemplified by the -111 kb-myf5 enhancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
TEAD1 | up-regulates quantity by expression
transcriptional regulation
|
MYF5 |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173445 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21527258 |
We found that the expression of myf5 and cyclind1 remained significantly elevated upon induction of differentiation in cells that were overexpressing hyap1 s127a compared to cells transfected with wildtype hyap and empty vector;yap directly induced the transcription of ccnd1 and foxm1, in cooperation with tead transcription factor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235599 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20153295 |
We found that the expression of myf5 and cyclind1 remained significantly elevated upon induction of differentiation in cells that were overexpressing hyap1 s127a compared to cells transfected with wildtype hyap and empty vector;yap directly induced the transcription of ccnd1 and foxm1, in cooperation with tead transcription factor. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Tissue: |
Muscle |
| + |
MYF5 | up-regulates quantity by expression
transcriptional regulation
|
DES |
0.243 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241494 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 8382796 |
Desmin, the muscle specific intermediate filament (IF) protein, is expressed at low levels in myoblasts and at the onset of differentiation its expression increases several fold. In an effort to explore the mechanism involved in the tissue-specific and developmentally regulated expression of desmin, we have isolated the mouse desmin gene.Co-transfection of myoD, myogenin, MRF4 and Myf5, with the desmin-CAT construct into 10T-1/2 cells demonstrated that all these factors could transactivate desmin gene expression |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PAX7/MLL2 complex | up-regulates quantity by expression
transcriptional regulation
|
MYF5 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198641 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 22863532 |
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
LEF1 | up-regulates quantity by expression
transcriptional regulation
|
MYF5 |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149170 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16936075 |
Furthermore, we show that direct activation is mediated by binding of the tcf-lef/ - catenin complex to the myf5 epaxial enhancer and to a newly identified element upstream of this enhancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
MYF5 | up-regulates
|
Skeletal_muscle_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37409 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8288123 |
The myogenic regulators myod, myogenin, myf5, and mrf4 share -80% amino acid identity within a basic helix-loop--helix (bhlh) motif that mediates dimerization and dna binding. / myogenic bhlh proteins form heterodimers with ubiquitous bhlh proteins, known as e proteins, and activate the transcription of muscle-specific genes by binding to the e-box consensus sequence (canntg) in muscle gene promoters and enhancers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling and Myogenesis |
| + |
WNT6 | up-regulates
|
MYF5 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60415 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9753670 |
Wnt4, wnt5a and wnt6 exert an intermediate effect activating both myf5 and myod equivalently in paraxial mesoderm. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYF5 | up-regulates quantity
transcriptional regulation
|
mir-206 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255917 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16731620 |
Moreover, both loci encoding miR-1, miR-1-1, and miR-1-2, and two of the three encoding miR-133, miR-133a-1 and miR-133a-2, are strongly induced during myogenesis.[…]By using CHIP analysis, we demonstrate that the myogenic factors Myogenin and MyoD bind to regions upstream of these microRNAs and, therefore, are likely to regulate their expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYF5 | up-regulates quantity
transcriptional regulation
|
MIR1-1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256241 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21730352 |
We provide evidence that PU.1 directly controls expression of at least 4 of these miRs (miR-146a, miR-342, miR-338, and miR-155) through temporally dynamic occupation of binding sites within regulatory chromatin regions adjacent to their genomic coding loci. We conclude that PU.1 bound to open chromatin near 4 of its induced miR loci with 2 types of kinetics: (1) permanent (miR-146a, miR-342, and miR-338) and (2) transient (miR-155) during myeloid differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WNT4 | up-regulates
|
MYF5 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60370 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9753670 |
Wnt4, wnt5a and wnt6 exert an intermediate effect activating both myf5 and myod equivalently in paraxial mesoderm. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
MYF5 | up-regulates activity
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255643 |
|
|
|
|
| pmid |
sentence |
| 17495111 |
In summary, the absence of Myf5 clearly reduced the initial expansion of satellite cell-derived transient amplifying cells and resulted in a shift of the ratio of satellite cell subpopulations but did not affect the specification and generation of specific subpopulations of satellite cell-derived cells such as reserve cells, amplifying cells, and differentiating mature myogenic cells. |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
| + |
SHH | up-regulates
|
MYF5 |
0.42 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179629 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 18662193 |
Shh reactivation plays a regulatory role on myogenesis, as its inhibition impairs the activation of the myogenic regulatory factors myf-5 and myod, decreases the up-regulation of insulin-like growth factor (igf)-1 and reduces the number of myogenic satellite cells at injured site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX7 | up-regulates quantity by expression
transcriptional regulation
|
MYF5 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255641 |
|
|
|
|
| pmid |
sentence |
| 18066051 |
Together, these experiments indicate that Pax7 enforces satellite cell commitment by recruiting a HMT complex to Myf5, resulting in transcriptional activation. |
|
| Publications: |
1 |
| + |
MDFI | down-regulates activity 
binding
|
MYF5 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240433 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8797820 |
We demonstrate that I-mf inhibits the transactivation activity of the MyoD family and represses myogenesis. I-mf associates with MyoD family members and retains them in the cytoplasm by masking their nuclear localization signals. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WNT5A | up-regulates activity
|
MYF5 |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60376 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9753670 |
Wnt4, wnt5a and wnt6 exert an intermediate effect activating both myf5 and myod equivalently in paraxial mesoderm. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
PAX7 | up-regulates quantity by expression
transcriptional regulation
|
MYF5 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255899 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29681515 |
Carm1 specifically methylates Pax7 at multiple arginine residues in the N terminus of Pax7, facilitating the recruitment of the ASH2L:MLL1/2:WDR5:RBBP5 histone H3 lysine 4 (H3K4) methyltransferase complex to the proximal promoter of Myf5 resulting in permissive H3K4 tri-methylation (H3K4me3) of the surrounding chromatin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WNT1 | up-regulates activity
|
MYF5 |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60285 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9753670 |
Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198849 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22944199 |
In explant cultures of mouse paraxial mesoderm, Wnt1 induced expression of the MRF Myf5, whereas Wnt7a or Wnt6 preferentially activated the MRF MyoD |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
MYF5 |
0.293 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176533 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Chen et al. showed that phosphorylated creb is present at high levels in cells of the dermomyotome that express pax3, myod and myf5 and that this phosphorylation is critical for the induction of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | WNT Signaling and Myogenesis |
| + |
PAX7/MLL1 complex | up-regulates quantity by expression
transcriptional regulation
|
MYF5 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198638 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 22863532 |
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
3.0
MYF5
- 
- 