| + |
AKT1 | up-regulates activity 
phosphorylation
|
RARG |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277492 |
Ser371 |
YARRRRPsQPYMFPR |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 31740618 |
S379 of RARγ is indispensable for the CLDN6-triggered cellular events. The most important finding of the present study is that the CLDN6/SFK/PI3K/AKT signaling controls the RARγ and ERα activities (Fig. 6). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAK complex | up-regulates activity
phosphorylation
|
RARG |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275969 |
Ser77 |
SEEMVPSsPSPPPPP |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10748061 |
Retinoic acid receptor gamma (RARgamma) is phosphorylated in COS-1 cells at two conserved serine residues located in the N-terminal region (serines 77 and 79 in RARgamma1 and serines 66 and 68 in RARgamma2) that contains the activation function AF-1. These serines are phosphorylated in vitro by cdk7, a cyclin-dependent kinase associated to cyclin H and MAT1 in the CAK complex (cdk7.cyclin H. MAT1), that is found either free or as a component of the transcription/DNA repair factor TFIIH. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275968 |
Ser79 |
EMVPSSPsPPPPPRV |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10748061 |
Retinoic acid receptor gamma (RARgamma) is phosphorylated in COS-1 cells at two conserved serine residues located in the N-terminal region (serines 77 and 79 in RARgamma1 and serines 66 and 68 in RARgamma2) that contains the activation function AF-1. These serines are phosphorylated in vitro by cdk7, a cyclin-dependent kinase associated to cyclin H and MAT1 in the CAK complex (cdk7.cyclin H. MAT1), that is found either free or as a component of the transcription/DNA repair factor TFIIH. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
CDK7 | up-regulates activity
phosphorylation
|
RARG |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259853 |
Ser77 |
SEEMVPSsPSPPPPP |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 10748061 |
RARg Is Phosphorylated by cdk7 in Its B and F Regions | Mutation into alanine of Ser-77 and Ser-79 located in the A/B region reduced the transcriptional activity of hRARg1 (Fig. 9A), confirming that these phosphorylation sites are required for optimal transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259852 |
Ser79 |
EMVPSSPsPPPPPRV |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 10748061 |
RARg Is Phosphorylated by cdk7 in Its B and F Regions | Mutation into alanine of Ser-77 and Ser-79 located in the A/B region reduced the transcriptional activity of hRARg1 (Fig. 9A), confirming that these phosphorylation sites are required for optimal transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277897 |
Ser79 |
EMVPSSPsPPPPPRV |
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 10748061 |
That phosphorylation of serines 77 and 79 by cdk7 could be responsible for efficient transcription was further supported by the observation that overexpressed cdk7 significantly enhanced transcription by hRARγ1WT but not by hRARγ1S77A/S79A (Fig. 9 B). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277896 |
Ser79 |
EMVPSSPsPPPPPRV |
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 10748061 |
That phosphorylation of serines 77 and 79 by cdk7 could be responsible for efficient transcription was further supported by the observation that overexpressed cdk7 significantly enhanced transcription by hRARγ1WT but not by hRARγ1S77A/S79A (Fig. 9 B). |
|
| Publications: |
4 |
Organism: |
Chlorocebus Aethiops |
| + |
THR | up-regulates
binding
|
RARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270315 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARG | up-regulates
binding
|
THRA |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133237 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARG | up-regulates
binding
|
RXRA |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16659 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic acid Signaling |
| + |
POU5F1 | up-regulates quantity 
|
RARG |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269222 |
|
|
|
|
| pmid |
sentence |
| 27499297 |
OCT4 positively controls the level of RARgamma |
|
| Publications: |
1 |
| + |
all-trans-retinoic acid | up-regulates activity
chemical activation
|
RARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258030 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 19058965 |
Tazarotene and its analogue 8 are RAR-β,γ selective acetylenic retinoids, whereas analogue 9 is very active on the three subtypes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256196 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17132853 |
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops, Homo Sapiens |
| Pathways: | Retinoic acid Signaling |
| + |
F2RL1 | down-regulates quantity by repression 
transcriptional regulation
|
RARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254858 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21072196 |
PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2) and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARG | up-regulates
binding
|
RXRB |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16662 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
RARG |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16683 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARG | up-regulates activity
binding
|
THR |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267804 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRA | up-regulates
binding
|
RARG |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16671 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic acid Signaling |
| + |
THR | up-regulates activity
binding
|
RARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267781 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARG | up-regulates
binding
|
THR |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270296 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
adapalene | up-regulates activity
chemical activation
|
RARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258488 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30836068 |
Adapalene, the third-generation synthetic retinoid,selectively bound to specific RAR, thus activating genes responsible forcellular differentiation. It showed greatest affinity for subtypes RARβ in dermal fibroblasts (Kd value 34 nM) and RARγ in the epidermis (Kdvalue 130 nM) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
THRA | up-regulates
binding
|
RARG |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133246 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid | up-regulates activity
chemical activation
|
RARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258140 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 19058965 |
Tazarotene and its analogue 8 are RAR-β,γ selective acetylenic retinoids, whereas analogue 9 is very active on the three subtypes. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
9-cis-retinoic acid | up-regulates activity
chemical activation
|
RARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259236 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18321241 |
Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
tazarotene | up-regulates activity
chemical activation
|
RARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258029 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 19058965 |
Tazarotene and its analogue 8 are RAR-β,γ selective acetylenic retinoids, whereas analogue 9 is very active on the three subtypes. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
RARG
- 
- 