| + |
PLK1 | up-regulates activity 
phosphorylation
|
CCNB1 |
0.919 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105707 |
Ser126 |
PILVDTAsPSPMETS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11242082 |
Phosphorylation of cyclin b1 is central to its nuclear translocationduring cell-cycle progression in hela cells, a change in the kinase activity of endogenous plk1 toward s147 and/or s133 correlates with a kinase activity in the cell extractsa mutant cyclin b1 in which s133 and s147 are replaced by alanines remains in the cytoplasm, whereas wild-type cyclin b1 accumulates in the nucleus during prophase.Together, these results suggest that phosphorylation of s133 and s147 is necessary for the nuclear translocation of cyclin b1 during prophase, and that phosphorylation of s126 and s128 may stimulate the nuclear translocation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105711 |
Ser128 |
LVDTASPsPMETSGC |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11242082 |
Phosphorylation of cyclin b1 is central to its nuclear translocationduring cell-cycle progression in hela cells, a change in the kinase activity of endogenous plk1 toward s147 and/or s133 correlates with a kinase activity in the cell extractsa mutant cyclin b1 in which s133 and s147 are replaced by alanines remains in the cytoplasm, whereas wild-type cyclin b1 accumulates in the nucleus during prophase.Together, these results suggest that phosphorylation of s133 and s147 is necessary for the nuclear translocation of cyclin b1 during prophase, and that phosphorylation of s126 and s128 may stimulate the nuclear translocation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105715 |
Ser133 |
SPSPMETsGCAPAEE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11242082 |
Phosphorylation of cyclin b1 is central to its nuclear translocationduring cell-cycle progression in hela cells, a change in the kinase activity of endogenous plk1 toward s147 and/or s133 correlates with a kinase activity in the cell extractsa mutant cyclin b1 in which s133 and s147 are replaced by alanines remains in the cytoplasm, whereas wild-type cyclin b1 accumulates in the nucleus during prophase.Together, these results suggest that phosphorylation of s133 and s147 is necessary for the nuclear translocation of cyclin b1 during prophase, and that phosphorylation of s126 and s128 may stimulate the nuclear translocation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105719 |
Ser147 |
EDLCQAFsDVILAVN |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11242082 |
Phosphorylation of cyclin b1 is central to its nuclear translocationduring cell-cycle progression in hela cells, a change in the kinase activity of endogenous plk1 toward s147 and/or s133 correlates with a kinase activity in the cell extractsa mutant cyclin b1 in which s133 and s147 are replaced by alanines remains in the cytoplasm, whereas wild-type cyclin b1 accumulates in the nucleus during prophase.Together, these results suggest that phosphorylation of s133 and s147 is necessary for the nuclear translocation of cyclin b1 during prophase, and that phosphorylation of s126 and s128 may stimulate the nuclear translocation. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
NFY | up-regulates quantity by expression 
transcriptional regulation
|
CCNB1 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235834 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10362252 |
In conclusion, our data demonstrate that nf-y is required for cyclin b1 promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
seliciclib | down-regulates 
chemical inhibition
|
CCNB1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-206562 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPRD1B | up-regulates quantity by expression
transcriptional regulation
|
CCNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265500 |
|
|
Homo sapiens |
MGC-803 Cell |
| pmid |
sentence |
| 30518842 |
These results indicated that CREPT regulates the Cyclin B1 expression via directly targeting its promoter region during transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APC-c | down-regulates quantity by destabilization
ubiquitination
|
CCNB1 |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265051 |
|
|
|
|
| pmid |
sentence |
| 21596315 |
Complexed with the activator proteins CDC20 or CDH1 (Fang et al., 1998, Visintin et al., 1997), the APC/C recognizes, ubiquitinates, and targets for proteasomal degradation a multitude of cell cycle regulators containing KEN or D box degrons, including securin, cyclin A, and cyclin B. |
|
| Publications: |
1 |
| + |
4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide | down-regulates
chemical inhibition
|
CCNB1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-193540 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCNB1 | form complex 
binding
|
CyclinB/CDK1 |
1 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205590 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25603287 |
The central mitotic kinase, cyclin-dependent kinase-1 (human cdk1 is present through all stages of the cell cycle, but its activity is cell-cycle regulated by phosphorylation/dephosphorylation and cyclin binding.Cdk1-cyclin b phosphorylates ser/thr residues directly preceding pro; thus, it is classified as a proline-directed kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HLX | up-regulates quantity by expression
transcriptional regulation
|
CCNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261619 |
|
|
Homo sapiens |
SGHPL-4 Cell |
| pmid |
sentence |
| 20008130 |
In this study, we have identified cell cycle regulatory genes as downstream targets of the homeobox gene HLX in cultured trophoblast cells, namely RB1, MYC, EGR1, CDKN1C, ELK1, CCNB1, and JUN. RB1 and MYC mRNA expression was increased with HLX inactivation, whereas EGR1, CDKN1C, ELK1, CCNB1, and JUN mRNA expression was decreased compared with mock-transfected control cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDC25A | up-regulates activity
dephosphorylation
|
CCNB1 |
0.849 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277137 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16682204 |
Cdc25A dephosphorylates and activates CyclinE\u2013Cdk2, CyclinA\u2013Cdk2 and CyclinB\u2013Cdk1, whereas Cdc25B and Cdc25C primarily target CyclinB\u2013Cdk1 [4,5] . |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKN1A | down-regulates
binding
|
CCNB1 |
0.823 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183498 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19158493 |
P21-mediated degradation of cyclin b1 in response to dna damage is necessary for the maintenance of g2 cell cycle arrest. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MXI1 | down-regulates quantity by repression
transcriptional regulation
|
CCNB1 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266064 |
|
|
Homo sapiens |
U-87MG Cell |
| pmid |
sentence |
| 11875718 |
Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression | Mxi1 inhibits the promoter activity of the cyclin B1 gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDC25C | up-regulates activity
dephosphorylation
|
CCNB1 |
0.825 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277099 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25949173 |
Cdc25C is an activator of Cdc2 kinase and dephosphorylates and activates the CyclinB-Cdc2 complex shortly before the entry into the mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDC20 | down-regulates quantity by destabilization
binding
|
CCNB1 |
0.966 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272578 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11285280 |
These results suggested that cyclin A is a target of the Cdc20-associated APC/C in human cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RFPL4A | down-regulates quantity by destabilization
ubiquitination
|
CCNB1 |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271476 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 12525704 |
We conclude that, like many RING-finger containing proteins, RFPL4 is an E3 ubiquitin ligase. The specificity of its expression and these interactions suggest that RFPL4 targets cyclin B1 for proteasomal degradation, a key aspect of oocyte cell cycle control during meiosis and the crucial oocyte-to-embryo transition to mitosis. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide | down-regulates
chemical inhibition
|
CCNB1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189969 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTCH1 | up-regulates
binding
|
CCNB1 |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199147 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331587 |
In addition, we demonstrate that endogenous ptc1 and endogenous cyclin B1 interact in vivo. The findings reported here demonstrate that ptc1 participates in determining the subcellular localization of cyclin B1 and suggest a link between the tumor suppressor activity of ptc1 and the regulation of cell division. Thus, we propose that ptc1 participates in a G2/M checkpoint by regulating the localization of MPF. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
R547 | down-regulates
chemical inhibition
|
CCNB1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-206349 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CCNB1
- 
- 