| + |
GSK3B | down-regulates quantity by destabilization 
phosphorylation
|
JUNB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276418 |
Ser251 |
QTVPEARsRDATPPV |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22710716 |
Thus, JunB phosphorylation at S251 and T255 by GSK3β is primed by phosphorylation at S259 by a yet to-be-identified kinase.Phosphorylation at S251, T255 and S259 is required for JunB degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276417 |
Thr255 |
EARSRDAtPPVSPIN |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22710716 |
Thus, JunB phosphorylation at S251 and T255 by GSK3β is primed by phosphorylation at S259 by a yet to-be-identified kinase.Phosphorylation at S251, T255 and S259 is required for JunB degradation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates 
phosphorylation
|
JUNB |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127545 |
Ser79 |
QGSDTGAsLKLASSE |
Homo sapiens |
|
| pmid |
sentence |
| 15308641 |
These results clearly demonstrate that phosphorylation by p38 kinase is essential for the regulation of dmp1 transcription by junb and p300. phosphorylation of junb at ser-79 was found to be essential for its interaction with p300. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8 | up-regulates activity
phosphorylation
|
JUNB |
0.72 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250120 |
Thr102 |
SNGVITTtPTPPGQY |
Mus musculus |
|
| pmid |
sentence |
| 9889198 |
JunB-control of IL-4 expression is mediated by the phosphorylation of JunB at Thr102 and -104 by JNK MAP kinase. The synergy between c-Maf and JunB can be attributed to cooperative DNA binding, which is facilitated by JunB phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250121 |
Thr104 |
GVITTTPtPPGQYFY |
Mus musculus |
|
| pmid |
sentence |
| 9889198 |
JunB-control of IL-4 expression is mediated by the phosphorylation of JunB at Thr102 and -104 by JNK MAP kinase. The synergy between c-Maf and JunB can be attributed to cooperative DNA binding, which is facilitated by JunB phosphorylation. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
SMAD3/SMAD4 | up-regulates quantity by expression 
transcriptional regulation
|
JUNB |
0.559 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59476 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9694870 |
Here we report the identification of Smad Binding Elements (SBEs) composed of the sequence CAGACA in the promoter of the JunB gene, an immediate early gene that is potently induced by TGF-beta, activin, and bone morphogenetic protein (BMP) 2. Two JunB SBEs are arranged as an inverted repeat that is transactivated in response to Smad3 and Smad4 co-overexpression and shows inducible binding of a Smad3- and Smad4-containing complex in nuclear extracts from TGF-beta-treated cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK9 | down-regulates
binding
|
JUNB |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53827 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9405416 |
Jnk targets junb ubiquitination |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JUNB | up-regulates quantity by expression
transcriptional regulation
|
IL4 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254503 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 21799768 |
Our results suggest that the prolonged IL-4 expression in NFAT1 deficient Th2 cells is mediated by preferential binding of JUNB/SATB1 to the IL-4 promoter with permissive chromatin architecture |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JUNB | down-regulates quantity by repression 
transcriptional regulation
|
LORICRIN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254535 |
|
|
Homo sapiens |
Keratinocyte |
| pmid |
sentence |
| 12200429 |
Loricrin expression is suppressed by Jun B, Sp3, and KSR-1 proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK12 | up-regulates quantity by expression
transcriptional regulation
|
JUNB |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67532 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10330170 |
Moreover, in addition to jnk, erk5, p38alpha, and p38gamma were found to stimulate the c-jun promoter by acting on distinct responsive elements. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ITCH | down-regulates quantity by destabilization
polyubiquitination
|
JUNB |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272619 |
|
|
Mus musculus |
T-lymphocyte Cell Line |
| pmid |
sentence |
| 11828324 |
Itch promotes Ub conjugation to JunB Molecularly, Itch associated with and induced ubiquitination of JunB, a transcription factor that is involved in TH2 differentiation. However, in Itch−/− T cells under the same conditions, degradation of JunB was markedly delayed. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Integrator complex | down-regulates quantity by repression
transcriptional regulation
|
JUNB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261479 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25675981 |
The Integrator complex controls the termination of transcription at diverse classes of gene targets.|Following INTS3 or INTS9 knockdown, the levels of SDC4, JUNB, FOSL1, and GADD45B increased, suggesting that the Integrator complex negatively regulates the transcription of these genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(-)-anisomycin | up-regulates
chemical activation
|
JUNB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189644 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates quantity by expression
transcriptional regulation
|
JUNB |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67535 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10330170 |
Moreover, in addition to jnk, erk5, p38alpha, and p38gamma were found to stimulate the c-jun promoter by acting on distinct responsive elements. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DMTF1 | up-regulates quantity by expression
transcriptional regulation
|
JUNB |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261585 |
|
|
Mus musculus |
C-10 Cell |
| pmid |
sentence |
| 19816943 |
Notably, amphiregulin (Areg), thrombospondin-1 (Tsp-1), JunB, Egr1, adrenomedullin (Adm), Bcl-3 and methyl-CpG binding domain protein 1 (Mbd1) were downregulated in the lungs from Dmp1-null mice while Gas1 and Ect2 genes were upregulated. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
JUNB
- 
- 