| + |
RAB5A | up-regulates activity 
binding
|
INPP5B |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277770 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33722976 |
We report that Rab5 acts at the plasma membrane, downstream of ruffling, to promote macropinosome sealing and scission. Rab5 is recruited to plasmalemmal circular ruffles before macropinosome closure. Rab5 effectors Inpp5b, OCRL and APPL1 localize to macropinocytic cups and vesicles, and are required for macropinosome sealing. The mammalian 5-phosphatases Inpp5b and OCRL, which can degrade PtdIns(4,5)P2, are both Rab5-associating effectors implicated in endocytosis and macropinocytosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB5A | up-regulates activity
binding
|
OCRL |
0.683 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277771 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33722976 |
We report that Rab5 acts at the plasma membrane, downstream of ruffling, to promote macropinosome sealing and scission. Rab5 is recruited to plasmalemmal circular ruffles before macropinosome closure. Rab5 effectors Inpp5b, OCRL and APPL1 localize to macropinocytic cups and vesicles, and are required for macropinosome sealing. The mammalian 5-phosphatases Inpp5b and OCRL, which can degrade PtdIns(4,5)P2, are both Rab5-associating effectors implicated in endocytosis and macropinocytosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ALS2 | up-regulates activity
binding
|
RAB5A |
0.725 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277776 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 30485418 |
ALS2 activates Rab5 on macropinosomes. Rab5 is activated and concurrently recruited to macropinosomes during ruffle closure. ALS2 depletion abolishes transient Rab5 activation on macropinosomes, while ALS2 is recruited to macropinosomes simultaneously with Rab5 activation. Thus, we conclude ALS2 activates Rab5 on macropinosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB5A | down-regulates activity 
binding
|
RAB7A |
0.684 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277780 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 30485418 |
The absence of active Rab7 prolongs ALS2presence and Rab5 activation on macropinosomes, indicating that activeRab7 is necessary for Rab5 inactivation through ALS2 dissociation and playskey roles in the Rab switch on macropinosomes. Taken together, active Rab7is necessary for Rab5 down-regulation through ALS2dissociation, thereby acting as a central component inthe Rab5-to-Rab7 switch in macropinocytosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LYST | down-regulates activity
binding
|
RAB5A |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266001 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 33725482 |
Mauve interacts with Rab5, Msps, and gamma-tubulin|Mauve/LYST opposes Rab5, which promotes vesicle fusion affecting PCM recruitment |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
RAB5A | up-regulates activity
binding
|
PIK3R4 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260708 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 27411398 |
Vps34 PI 3-kinase activity18 is stimulated by complex formation with the protein kinase Vps15|Rab5GTP binds Vps15, enhancing Vps34 activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RAB5A | up-regulates activity
binding
|
COMMD5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261691 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30021164 |
The N terminus of COMMD5 binds to the endosomal Rab5, and its C terminus, including the COMMD domain, binds to the cytoskeletal scaffolding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RABGGTB | up-regulates activity
lipidation
|
RAB5A |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265573 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18532927 |
Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this complex then binds and prenylates Rab proteins. Rab GTPases need to be geranylgeranylated on either one or two cysteine residues in their Ctermini in order to localize to the correct intracellular membrane and be functional |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RABGGTA | up-regulates activity
lipidation
|
RAB5A |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265572 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18532927 |
Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this complex then binds and prenylates Rab proteins. Rab GTPases need to be geranylgeranylated on either one or two cysteine residues in their Ctermini in order to localize to the correct intracellular membrane and be functional |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SUN2 | up-regulates activity
binding
|
RAB5A |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261309 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10818110 |
Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RABGEF1 | up-regulates activity
guanine nucleotide exchange factor
|
RAB5A |
0.921 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260707 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 27411398 |
AP-1/sigma1A-ArfGAP1-Rabex-5 complex formation leads to more endosomal Rabex-5 and enhanced, Rab5GTP-stimulated Vps34 PI3-kinase activity, which is essential for multivesicular body endosome formation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RAB5A | form complex 
binding
|
Early Endosome |
0.535 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260616 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19924646 |
The Rab proteins primarily localized to the EE include Rab5 and Rab4, which regulate distinct early endocytic events. In addition to these two Rab proteins, some of the other less well-characterized Rabs at the EE include Rab10 , Rab14 , Rab21 and Rab22 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RABEP1 | up-regulates
binding
|
RAB5A |
0.927 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109352 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11452015 |
We have previously shown that rab5, which regulates various steps of transport along the early endocytic pathway, is activated by a complex consisting of rabex-5, a rab5 nucleotide exchange factor, and the effector rabaptin-5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RABGEF1 | up-regulates
binding
|
RAB5A |
0.921 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109398 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11452015 |
We have previously shown that rab5, which regulates various steps of transport along the early endocytic pathway, is activated by a complex consisting of rabex-5, a rab5 nucleotide exchange factor, and the effector rabaptin-5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RAB5A
- 
- 