| + |
EEA1 | form complex 
binding
|
Early Endosome |
0.564 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260623 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19924646 |
Early endosomal antigen-1 (EEA1) is a well-characterized effector of Rab5 and one of the most widely used markers for EE due to its specific localization to this compartment. EEA1, in coordination with members of the SNARE family, is essential for EE fusion in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AP-3/clathrin vescicle | up-regulates activity 
relocalization
|
Early Endosome |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260712 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23144738 |
Rabip4' colocalized with AP-3 on a tubular subdomain of early endosomes and the extent of colocalization was increased by a dominant negative rab4 mutant. Knock-down of AP-3 had an ever more dramatic effect and caused accumulation of lysosomes in protrusions at the plasma membrane. The most peripheral lysosomes were localized beyond microtubules, within the cortical actin network. Our results uncover a novel function for AP-3 and rabip4' in regulating lysosome positioning through an interorganellar pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACTB | up-regulates 
|
Early Endosome |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260610 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19121306 |
However, we did detect WAFL binding to bothWIP and actin by immunoprecipitation (Fig. 4). In conclusion, we propose a model whereby WAFL associates toendocytic vesicles by its coiled-coil domain and is involved in actin-based movement of early endosomes via WIP and binding to actin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB21 | form complex
binding
|
Early Endosome |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260620 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19924646 |
The Rab proteins primarily localized to the EE include Rab5 and Rab4, which regulate distinct early endocytic events. In addition to these two Rab proteins, some of the other less well-characterized Rabs at the EE include Rab10 , Rab14 , Rab21 and Rab22 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB10 | form complex
binding
|
Early Endosome |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260618 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19924646 |
The Rab proteins primarily localized to the EE include Rab5 and Rab4, which regulate distinct early endocytic events. In addition to these two Rab proteins, some of the other less well-characterized Rabs at the EE include Rab10 , Rab14 , Rab21 and Rab22 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBSN | form complex
binding
|
Early Endosome |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260624 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19924646 |
Rabenosyn-5 is another FYVE-domain-containing Rab5 effector that localizes to EE |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB14 | form complex
binding
|
Early Endosome |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260619 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19924646 |
The Rab proteins primarily localized to the EE include Rab5 and Rab4, which regulate distinct early endocytic events. In addition to these two Rab proteins, some of the other less well-characterized Rabs at the EE include Rab10 , Rab14 , Rab21 and Rab22 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB5A | form complex
binding
|
Early Endosome |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260616 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19924646 |
The Rab proteins primarily localized to the EE include Rab5 and Rab4, which regulate distinct early endocytic events. In addition to these two Rab proteins, some of the other less well-characterized Rabs at the EE include Rab10 , Rab14 , Rab21 and Rab22 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB5B | form complex
binding
|
Early Endosome |
0.481 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276874 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19924646 |
The Rab proteins primarily localized to the EE include Rab5 and Rab4, which regulate distinct early endocytic events. In addition to these two Rab proteins, some of the other less well-characterized Rabs at the EE include Rab10 , Rab14 , Rab21 and Rab22 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Early Endosome | up-regulates quantity
binding
|
ESCRT-0 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280930 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22361144 |
The ESCRT-0 complex initiates the MVB pathway. It is the first complex of the ESCRT machinery that localizes to endosomes and does so via an interaction with an endosome-enriched phospholipid, phosphatidylinositol-3-phosphate (PI3P) (Figure 2). On endosomes, ESCRT-0 binds to ubiquitin moieties that are attached to membrane proteins destined for degradation, and thus executes the first sorting step in the MVB pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIF13A | up-regulates
relocalization
|
Early Endosome |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260703 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30404817 |
Recycling endosomes (REs) are transient endosomal tubular intermediates of early/sorting endosomes (E/SEs) that function in cargo recycling to the cell surface and deliver the cell type-specific cargo to lysosome-related organelles such as melanosomes in melanocytes.|Taken together, these findings suggest that Rab22A promotes the assembly of a BLOC-1-BLOC-2-KIF13A complex on E/SEs to generate REs that maintain cellular and organelle homeostasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB4A | form complex
binding
|
Early Endosome |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260617 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19924646 |
The Rab proteins primarily localized to the EE include Rab5 and Rab4, which regulate distinct early endocytic events. In addition to these two Rab proteins, some of the other less well-characterized Rabs at the EE include Rab10 , Rab14 , Rab21 and Rab22 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB22A | form complex
binding
|
Early Endosome |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260621 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19924646 |
The Rab proteins primarily localized to the EE include Rab5 and Rab4, which regulate distinct early endocytic events. In addition to these two Rab proteins, some of the other less well-characterized Rabs at the EE include Rab10 , Rab14 , Rab21 and Rab22 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1-phosphatidyl-1D-myo-inositol 3-phosphate | form complex
binding
|
Early Endosome |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260622 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19924646 |
PtdIns(3)P-kinase/hVPS34/p150 (VPS34) is thought to be one of the first Rab5 effector proteins to be recruited to the EE . As suggested by its name, its primary role is to generate PtdIns(3)P, which is the most abundant phosphoinositide in the EE membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WIPF1 | up-regulates
|
Early Endosome |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260611 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19121306 |
However, we did detect WAFL binding to bothWIP and actin by immunoprecipitation (Fig. 4). In conclusion, we propose a model whereby WAFL associates toendocytic vesicles by its coiled-coil domain and is involved in actin-based movement of early endosomes via WIP and binding to actin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Early Endosome