Summary

Name EFNA1
Full Name Ephrin-A1
Synonyms EPH-related receptor tyrosine kinase ligand 1, LERK-1, Immediate early response protein B61, Tumor necrosis factor alpha-induced protein 4, TNF alpha-induced protein 4 | EPLG1, LERK1, TNFAIP4
Primary ID P20827
Links - -
Type protein
Relations 14
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding EPHA1 0.99
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA8
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation EFNA1 0.26
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA3 0.60
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA4 0.89
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA2 1.00
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA5 0.93
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA6 0.75
Publications: 1 Organism: Homo Sapiens