| + |
PTPRB | down-regulates activity 
dephosphorylation
|
KDR |
0.464 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248441 |
Tyr1175 |
AQQDGKDyIVLPISE |
Homo sapiens |
|
| pmid |
sentence |
| 19136612 |
VE-PTP/VEGFR2 complex formation resumes with time, leading to dephosphorylation and deactivation of VEGFR2 (right). B) In VE-PTP-deficient cells, such as after siRNA treatment, VEGFR2 activation (middle) is exaggerated, leading to increased phosphorylation at the Y951 and Y1175 phosphorylation sites |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRB | down-regulates
dephosphorylation
|
INSR |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75989 |
Tyr1185 |
FGMTRDIyETDYYRK |
Homo sapiens |
|
| pmid |
sentence |
| 10734133 |
Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75993 |
Tyr1189 |
RDIYETDyYRKGGKG |
Homo sapiens |
|
| pmid |
sentence |
| 10734133 |
Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75997 |
Tyr1190 |
DIYETDYyRKGGKGL |
Homo sapiens |
|
| pmid |
sentence |
| 10734133 |
Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-76001 |
Tyr999 |
YASSNPEyLSASDVF |
Homo sapiens |
|
| pmid |
sentence |
| 10734133 |
Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
PTPRB | down-regulates
dephosphorylation
|
MET |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173004 |
Tyr1356 |
YVHVNATyVNVKCVA |
Homo sapiens |
|
| pmid |
sentence |
| 21454675 |
Receptor-type protein tyrosine phosphatase beta (rptp-beta) directly dephosphorylates and regulates hepatocyte growth factor receptor (hgfr/met) function. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139560 |
Tyr1356 |
YVHVNATyVNVKCVA |
Homo sapiens |
|
| pmid |
sentence |
| 16101282 |
Ptp1b and shp-2 are bound to the c-met receptor to control its activity. Although the binding of ptp1b increases when there is a decrease in c-met activation and acts as a negative regulator of the receptor, the increased binding and phosphorylation of shp-2 coincide with maximal stimulation of c-met, acting as a positive regulator. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PTPRB | down-regulates activity
dephosphorylation
|
MET |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248440 |
Tyr1356 |
YVHVNATyVNVKCVA |
Homo sapiens |
|
| pmid |
sentence |
| 21454675 |
Receptor-type protein tyrosine phosphatase beta (RPTP-beta) directly dephosphorylates and regulates hepatocyte growth factor receptor (HGFR/Met) function.|Expression of RPTP-β in primary human keratinocytes reduces both basal and HGF-induced Met phosphorylation at tyrosine 1356 and inhibits downstream MEK1/2 and Erk activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRB | down-regulates activity
dephosphorylation
|
NOS3 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277521 |
Tyr81 |
WEVGSITyDTLSAQA |
Homo sapiens |
|
| pmid |
sentence |
| 32653904 |
VE-PTP interacts with eNOS and dephosphorylates Tyr81 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277041 |
Tyr81 |
WEVGSITyDTLSAQA |
Homo sapiens |
|
| pmid |
sentence |
| 32653904 |
VE-PTP inhibition enhances eNOS activity to improve endothelial function and decrease blood pressure indirectly, through the activation of Tie-2 and the CD31/VE, cadherin, and VEGFR2 complex, and directly by dephosphorylating eNOS Tyr81.|VE-PTP, on the other hand, formed a complex with eNOS in endothelial cells and directly dephosphorylated eNOS Tyr81 in vitro. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PTPRB | down-regulates activity
dephosphorylation
|
TEK |
0.57 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277059 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34417472 |
Simultaneous inhibition of Tie2 cleavage and VE-PTP synergistically enhances Tie2 activation by up to 10-fold (Fig. 7A).|Tie2 activation is also importantly regulated by vascular endothelial protein tyrosine phosphatase (VE-PTP), which dephosphorylates Tie2 to inhibit its vascular stabilizing effects .|Tie2 activation is also importantly regulated by vascular endothelial protein tyrosine phosphatase (VE-PTP), which dephosphorylates Tie2 to inhibit its vascular stabilizing effects. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRB | down-regulates activity
dephosphorylation
|
SRC |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277132 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27314562 |
Collectively, these results suggest that PTPRB inhibits Src activation and down -- regulation of PTPRB activates Src signalling pathway required for cell invasion in A549 cells.|Knockdown of PTPRB increased Src phosphorylation and cell invasion, which was reversed by Src inhibitor PP2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRB | down-regulates
dephosphorylation
|
MAPK1 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173000 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21454675 |
Expression of rptp-beta inhibits both mek1/2 and erk1/2 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRB | down-regulates
dephosphorylation
|
GHR |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104580 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12907755 |
Inally, mrna tissue distribution of these ptps by rt-pcr analysis and coexpression of the wild-type ptps to test their ability to dephosphorylate ligand-activated ghr suggest ptp-h1 and ptp1b as potential candidates involved in ghr signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRB | down-regulates
dephosphorylation
|
ALK |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157175 |
|
|
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 17681947 |
Rptpbeta/zeta dephosphorylates alk at the site(s) in alk that is undergoing autophosphorylation through autoactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRB | up-regulates 
dephosphorylation
|
MAPK3 |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103165 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12840032 |
When cells are stimulated with various ligands such as growth factors, hormones, neurotransmitters, or tumor promoters, erk1/2 is activated through dualphosphorylation at the -ptepy-motif. Subsequently, p-erk1/2 translocates into the nucleus and phosphorylates elk-1, thereby acting as a transcription factor for cell proliferationthese data indicate that sa-p-erk1/2 might not only be regulated by mkp such as rvhr, but also by pp1 and ptp as well |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRB | up-regulates
dephosphorylation
|
ERK1/2 |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269931 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12840032 |
When cells are stimulated with various ligands such as growth factors, hormones, neurotransmitters, or tumor promoters, erk1/2 is activated through dualphosphorylation at the -ptepy-motif. Subsequently, p-erk1/2 translocates into the nucleus and phosphorylates elk-1, thereby acting as a transcription factor for cell proliferationthese data indicate that sa-p-erk1/2 might not only be regulated by mkp such as rvhr, but also by pp1 and ptp as well |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRB | up-regulates
dephosphorylation
|
Gbeta |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269911 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12840032 |
When cells are stimulated with various ligands such as growth factors, hormones, neurotransmitters, or tumor promoters, erk1/2 is activated through dualphosphorylation at the -ptepy-motif. Subsequently, p-erk1/2 translocates into the nucleus and phosphorylates elk-1, thereby acting as a transcription factor for cell proliferationthese data indicate that sa-p-erk1/2 might not only be regulated by mkp such as rvhr, but also by pp1 and ptp as well |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRB | up-regulates activity
dephosphorylation
|
CDH5 |
0.598 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277131 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19015309 |
Because we had shown previously that VE-PTP supports VE-cadherin function when exogenously expressed in transfected cells, we expected it to be expressed at endothelial cell contacts.|Indeed, tyrosine phosphorylation of VE-cadherin is reduced by VE-PTP in COS-7 and CHO cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PTPRB
- 
- 