3.0
Summary
| Name |  CCND3View Modifications |
| Full Name | G1/S-specific cyclin-D3 |
| Synonyms | CCND3_HUMAN |
| Primary ID | P30281 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Inhibitors | 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide |
| Function | Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PPP1CA | up-regulates 
dephosphorylation
|
CCND3 | 0.248 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GSK3B | down-regulates 
phosphorylation
|
CCND3 | 0.415 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PP1 | up-regulates
dephosphorylation
|
CCND3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ROBO | down-regulates
phosphorylation
|
CCND3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXL2 | down-regulates quantity by destabilization
binding
|
CCND3 | 0.498 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MYOD1 | up-regulates quantity by expression
transcriptional regulation
|
CCND3 | 0.383 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | CCND3 | form complex 
binding
|
CyclinD3/CDK11A | 0.403 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CCND3 | up-regulates 
|
Cell_cycle_exit | 0.7 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | CCND3 | form complex
binding
|
CyclinD3/CDK6 | 0.933 |
| Publications: | 1 | |||
| + | Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
CCND3 | 0.422 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CCND3 | form complex
binding
|
CyclinD3/CDK11B | 0.637 |
| Publications: | 1 | Organism: | In Vitro | |
| + | 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide | down-regulates
chemical inhibition
|
CCND3 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |