Summary

Name CCND3
Full Name G1/S-specific cyclin-D3
Synonyms CCND3_HUMAN
Primary ID P30281
Links - -
Type protein
Relations 12
Inhibitors 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide
Function Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png dephosphorylation CCND3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CCND3 0.412
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation CCND3 0.248
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CCND3 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CyclinD3/CDK11A 0.406
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CCND3 0.502
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CCND3 0.388
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination CCND3 0.42
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CyclinD3/CDK11B 0.634
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding CyclinD3/CDK6 0.932
Publications: 1
+ up-regulates img/indirect-activation.png Cell_cycle_exit 0.7
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png chemical inhibition CCND3 0.8
Publications: 1 Organism: Homo Sapiens