Summary

Name RYK
Full Name Tyrosine-protein kinase RYK
Synonyms RYK_HUMAN | JTK5A
Primary ID P34925
Links - -
Type protein
Relations 9
Function May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

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Relations

Regulator Mechanism target score ℹ
+ WNT1up-regulates img/direct-activation.png binding RYK 0.697
Publications: 1 Organism: Homo Sapiens
+ WNT3Aup-regulates img/direct-activation.png binding RYK 0.754
Publications: 1 Organism: Homo Sapiens
+ WNT5Aup-regulates img/direct-activation.png binding RYK 0.776
Publications: 1 Organism: Homo Sapiens
+ RYKup-regulates img/direct-activation.png binding FZD8 0.699
Publications: 1 Organism: Homo Sapiens
+ MIB1down-regulates img/direct_inhibition.png ubiquitination RYK 0.333
Publications: 1 Organism: Homo Sapiens
+ RYKup-regulates img/direct-activation.png binding DVL3 0.413
Publications: 1 Organism: Homo Sapiens
+ RYKup-regulates img/direct-activation.png binding DVL1 0.497
Publications: 1 Organism: Homo Sapiens
+ RYKup-regulates img/direct-activation.png binding DVL2 0.43
Publications: 1 Organism: Homo Sapiens
+ PSENENup-regulates img/direct-activation.png cleavage RYK 0.2
Publications: 1 Organism: Homo Sapiens