Summary

Name CTNNA1
Full Name Catenin alpha-1
Synonyms Alpha E-catenin, Cadherin-associated protein, Renal carcinoma antigen NY-REN-13
Primary ID P35221
Links - -
Type protein
Relations 5
Pathways Hippo Signaling
Function Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ CSNK2A1down-regulates img/direct_inhibition.png phosphorylation CTNNA1 0.4
Publications: 1 Organism: Homo Sapiens
+ PTPN11down-regulates img/direct_inhibition.png dephosphorylation CTNNA1 0.405
Publications: 1 Organism: Homo Sapiens
+ CDH11 img/unknown.png binding CTNNA1 0.463
Publications: 1 Organism: Homo Sapiens
+ CDH1up-regulates img/direct-activation.png binding CTNNA1 0.67
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ CTNNA1down-regulates img/direct_inhibition.png binding YAP1 0.36
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling