Hippo Signaling

Pathway ID: SIGNOR-HPPView in NDEx

Description: The Hippo pathway controls organ size in diverse species by regulating cell proliferation, apoptosis, and stem cell self renewal. Actin cytoskeleton or cellular tension appears to be the master mediator that integrates and transmits upstream signals to the core Hippo signaling cascade.

Curated by: Milica Marinkovic

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

23 Seed Entities

Organism:
Name Primary ID
YAP1 P46937
TEAD SIGNOR-PF22
AMOT/MPP5/INADL/LIN7C SIGNOR-C27
CSNK1D P48730
TAOK SIGNOR-PF21
LATS2 Q9NRM7
SAV1 Q9H4B6
SCF-betaTRCP SIGNOR-C5
RASSF1 Q9NS23
LATS1 O95835
CDH1 P12830
TJP2 Q9UDY2
MOB1A Q9H8S9
Proliferation SIGNOR-PH4
WWTR1 Q9GZV5
STK4 Q13043
Apoptosis SIGNOR-PH2
F-actin Assembly SIGNOR-PH18
CTNNA1 P35221
MOB1B Q7L9L4
CSNK1E P49674
STK3 Q13188
14-3-3 SIGNOR-PF7