Summary

Name NOS2
Full Name Nitric oxide synthase, inducible
Synonyms Hepatocyte NOS, HEP-NOS, Inducible NO synthase, Inducible NOS, iNOS, NOS type II, Peptidyl-cysteine S-nitrosylase NOS2 | NOS2A
Primary ID P35228
Links - -
Type protein
Relations 9
Function Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation NOS2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png L-citrulline 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png NOS2 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/indirect-activation.png transcriptional regulation NOS2 0.14
Publications: 1
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOS2 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOS2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png nitric oxide 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png NOS2 0.14
Publications: 1
Tissue: Skeletal Muscle