| + |
IL23A | up-regulates 
binding
|
IL12RB1 |
0.645 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99716 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12671732 |
Based on these analyses, we propose an integrated model of il-12rbeta1 structure and function. This significantly enhances our molecular understanding of the human il-12 and il-23 systems. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87739 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12023369 |
Like il-12, il-23 binds to the il-12r subunit il-12rbeta1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
IL12B | up-regulates
binding
|
IL12RB1 |
0.676 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-27690 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7527811 |
Characterization of the p40 proteins for binding and bioactivity showed that both the p40 monomer and dimer inhibited 125i-labeled il-12 binding to il-12r, but the 80-kda species, having a 50% inhibitory concentration (ic50) of 20 to 70 ng/ml, was at least 20-fold more effective than the monomer. The results suggest that the il-12 p40 subunit contains the essential epitopes for receptor binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL12A | up-regulates
binding
|
IL12RB1 |
0.572 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87677 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12023369 |
Like il-12, il-23 binds to the il-12r subunit il-12rbeta1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL12RB1 | form complex 
binding
|
Interleukin-23 receptor-ligand complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280727 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12023369 |
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit some activities similar to IL-12, but differ in their capacities to stimulate particular populations of memory T cells. Like IL-12, IL-23 binds to the IL-12R subunit IL-12Rbeta1. However, it does not use IL-12Rbeta2. In this study, we identify a novel member of the hemopoietin receptor family as a subunit of the receptor for IL-23, "IL-23R." IL-23R pairs with IL-12Rbeta1 to confer IL-23 responsiveness on cells expressing both subunits. IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
IL12RB1
- 
- 