3.0
Summary
| Name |  PIK3CBView Modifications |
| Full Name | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| Synonyms | PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, PtdIns-3-kinase subunit beta, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, PtdIns-3-kinase subunit p110-beta, p110beta | PIK3C1 |
| Primary ID | P42338 |
| Links |  -  -  |
| Type | protein |
| Relations | 33 |
| Pathways | Adipogenesis, Insulin Signaling |
| Inhibitors | PI-103; IC-87114; GSK1059615; GSK2126458; ZSTK-474; BKM120; PKI-402; PP121; dactolisib; PIK-90; XL765; CH5132799; pictrelisib; 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-9-pyrido[1,2-a]pyrimidinyl]ethyl]amino]benzoic acid; 1-[4-[[2-(2-amino-5-pyrimidinyl)-7-methyl-4-(4-morpholinyl)-6-thieno[3,2-d]pyrimidinyl]methyl]-1-piperazinyl]-2-hydroxy-1-propanone; 9-(1-anilinoethyl)-7-methyl-2-(4-morpholinyl)-4-pyrido[1,2-a]pyrimidinone |
| Function | Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PIK3CB | down-regulates activity 
phosphorylation
|
PIK3CB | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | Adipogenesis, Insulin Signaling | |||
| + | TNF | up-regulates 
|
PIK3CB | 0.257 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PI-103 | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IC-87114 | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GSK1059615 | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KRAS | up-regulates 
binding
|
PIK3CB | 0.701 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Adipogenesis | |||
| + | PI3K | up-regulates activity
binding
|
PIK3CB | 0.623 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | GSK2126458 | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ZSTK-474 | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BKM120 | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PKI-402 | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IRS1 | up-regulates activity
binding
|
PIK3CB | 0.712 |
| Publications: | 2 | Organism: | Mus Musculus | |
| Tissue: | Muscle | |||
| Pathways: | Adipogenesis, Insulin Signaling | |||
| + | ITGB4 | up-regulates
binding
|
PIK3CB | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERBB3 | up-regulates
binding
|
PIK3CB | 0.5 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PP121 | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | dactolisib | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PIK-90 | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERBB4 | up-regulates
binding
|
PIK3CB | 0.463 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | XL765 | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PIK3CB | up-regulates
|
Survival | 0.7 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | NRAS | up-regulates
binding
|
PIK3CB | 0.653 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CH5132799 | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | pictrelisib | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Breast | |||
| + | PTEN | down-regulates activity 
|
PIK3CB | 0.671 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Insulin Signaling | |||
| + | 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-9-pyrido[1,2-a]pyrimidinyl]ethyl]amino]benzoic acid | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 1-[4-[[2-(2-amino-5-pyrimidinyl)-7-methyl-4-(4-morpholinyl)-6-thieno[3,2-d]pyrimidinyl]methyl]-1-piperazinyl]-2-hydroxy-1-propanone | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CRKL | up-regulates activity
binding
|
PIK3CB | 0.451 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HRAS | up-regulates activity
binding
|
PIK3CB | 0.748 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Insulin Signaling | |||
| + | PIK3CB | up-regulates quantity
chemical modification
|
PIP3 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Adipogenesis, Insulin Signaling | |||
| + | PIK3AP1 | up-regulates
binding
|
PIK3CB | 0.397 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 9-(1-anilinoethyl)-7-methyl-2-(4-morpholinyl)-4-pyrido[1,2-a]pyrimidinone | down-regulates
chemical inhibition
|
PIK3CB | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PIK3R1 | up-regulates activity
binding
|
PIK3CB | 0.845 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |