Relation Results

Summary

Name MAP4K3
Full Name Mitogen-activated protein kinase kinase kinase kinase 3
Synonyms Germinal center kinase-related protein kinase, GLK, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, MEKKK 3 | RAB8IPL1
Primary ID Q8IVH8
Links - -
Type protein
Relations 6
Function May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

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Type: Score: Layout: SPV 
0.20.20.2510.20.3810.449MKRN4PMAP4K3TFEBIQGAP1PRKCQMAP3K1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MKRN4Pdown-regulates quantity img/direct_inhibition.png ubiquitination MAP4K3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278658 Lys650 PVAIPAHkLPDRILP Homo sapiens
pmid sentence
MKRN4 ubiquitinated GLK at Lys650 residue.|Remarkably, MKRN4 overexpression induced GLK protein degradation in HEK293T cells and Jurkat T cells (figure 5A and B).
Publications: 1 Organism: Homo Sapiens
+ MAP4K3up-regulates img/direct-activation.png phosphorylation MAP4K3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-164103 Ser170 ATIAKRKsFIGTPYW Homo sapiens
pmid sentence
We identify a transautophosphorylation site in the map4k3 kinase activation segment (ser170) that is required for map4k3 activity and its activation of mtorc1 signaling.
Publications: 1 Organism: Homo Sapiens
+ MAP4K3down-regulates activity img/direct_inhibition.png phosphorylation TFEB 0.251
Identifier Residue Sequence Organism Cell Line
SIGNOR-278282 Ser3 sRIGLRMQ Homo sapiens
pmid sentence
However, although our results indicate that MAP4K3 initiates TFEB repression, MAP4K3 also promotes robust mTORC1 activation upon amino acid stimulation - ; hence, MAP4K3 and mTORC1 must ultimately work together to achieve robust suppression of autophagy.|Moreover, MAP4K3 serine 3 phosphorylation of TFEB is required for TFEB interaction with mTORC1-Rag GTPase-Ragulator complex and TFEB cytosolic sequestration.
Publications: 1 Organism: Homo Sapiens
+ MAP4K3up-regulates activity img/direct-activation.png phosphorylation IQGAP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277479 Ser480 NTVWKQLsSSVTGLT in vitro
pmid sentence
GLK directly phosphorylated IQGAP1 at Ser-480 enhancing Cdc42 activation and subsequent cell migration. 
Publications: 1 Organism: In Vitro
+ MAP4K3up-regulates img/direct-activation.png phosphorylation PRKCQ 0.381
Identifier Residue Sequence Organism Cell Line
SIGNOR-176744 Thr538 LGDAKTNtFCGTPDY Homo sapiens T-lymphocyte
pmid sentence
We report that the kinase glk (map4k3) directly activated pkc-? During tcr signaling.
Publications: 1 Organism: Homo Sapiens
+ MAP4K3up-regulates img/direct-activation.png phosphorylation MAP3K1 0.449
Identifier Residue Sequence Organism Cell Line
SIGNOR-61814 Homo sapiens
pmid sentence
With regard to at least mekk1, serine/threonine kinases such as nik,glkand hpk1 appear also to be important for regulation
Publications: 1 Organism: Homo Sapiens
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