+ |
CDK1 |
phosphorylation
|
RAP1GAP |
0.457 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-18735 |
Ser484 |
SLIVPGKsPTRKKSG |
Homo sapiens |
|
pmid |
sentence |
1406653 |
Two of the sites of phosphorylation by cyclic amp (camp)-dependent kinase were localized to serine residues 490 and 499, and one site of phosphorylation by p34cdc2 was localized to serine 484. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PRKACA |
phosphorylation
|
RAP1GAP |
0.313 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250043 |
Ser490 |
KSPTRKKsGPFGSRR |
in vitro |
|
pmid |
sentence |
1406653 |
We have localized two of the sites of phosphorylation in vitro by cAMP-dependent kinase to serine residues 490 and 499. raplGAP undergoes phosphorylation at specific sites in vivo, the effects of phosphorylation on raplGAP have remained elusive. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250044 |
Ser499 |
PFGSRRSsAIGIENI |
in vitro |
|
pmid |
sentence |
1406653 |
We have localized two of the sites of phosphorylation in vitro by cAMP-dependent kinase to serine residues 490 and 499. raplGAP undergoes phosphorylation at specific sites in vivo, the effects of phosphorylation on raplGAP have remained elusive. |
|
Publications: |
2 |
Organism: |
In Vitro |
+ |
PLK1 | down-regulates
phosphorylation
|
RAP1GAP |
0.464 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-205577 |
Ser525 |
AGQKTPDsGHVSQEP |
Homo sapiens |
|
pmid |
sentence |
25329897 |
Plk1 phosphorylates ser525 in conserved 524dsghvs529 degron of rap1gap and promotes its interaction with _-trcp. Together, these results further support a model in which plk1, but not cdk1 or gsk-3_-mediated phosphorylation of rap1gap is a prerequisite for mitotic degradation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
BTRC | down-regulates
ubiquitination
|
RAP1GAP |
0.348 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-203548 |
|
|
Homo sapiens |
|
pmid |
sentence |
25329897 |
Here, we demonstrated that rap1gap is ubiquitinated and degraded through proteasome pathway in mitosis. Proteolysis of rap1gap requires the plk1 kinase and _-trcp ubiquitin ligase complex. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |