| + |
IGF1 | down-regulates quantity by repression 
transcriptional regulation
|
MMP13 |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254802 |
|
|
Homo sapiens |
Chondrocyte Cell Line |
| pmid |
sentence |
| 12734180 |
In the present study we investigated the inhibitory effects of IGF-1 and OP-1 on MMP-13 expression in human chondrocytes. We found that the suppressive effect of IGF-1 and OP-1 on the MMP-13 promoter activity was dose-dependent at the transcriptional level with a corresponding decrease in the level of MMP-13 protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT5A | up-regulates quantity by expression 
transcriptional regulation
|
IGF1 |
0.446 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251743 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 10050749 |
Growth hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1α |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
| + |
SOX17/POU5F1 | up-regulates quantity by expression
transcriptional regulation
|
IGF1 |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269258 |
|
|
|
|
| pmid |
sentence |
| 31583686 |
Both SOX2 and SOX17 are able to partner with OCT4 and, as a consequence, recognize and bind specific binding motifs.6, 7 In human and mouse ESCs, SOX2/OCT4 bind to canonical motifs (CTTTGTCATGCAAAT-like), which are composite SOX (CATTGTC-like) and OCT (ATGCAAAT-like) motifs|This way SOX17 and SOX2 regulate a common set of pluripotency and GC-related genes (PRDM14, DPPA4, TDGF1, NANOG, LIN28A, TRIM71, OTX2, PIM2) (Fig. 6). Additionally, in TCam-2 cells SOX17 binds to compressed motifs or SOX motifs (not bound by SOX2 in ECs), thereby regulating the PGC specifiers PRDM1 and TFAP2C, the GC-related genes NANOS3 and BMP7 and the cancer-related genes MYC and IGF1 (Fig. 6). In 2102EP cells, SOX2 further binds canonical elements or SOX motifs (not bound by SOX17 in TCam-2), regulating additional pluripotency genes (GDF3, LEFTY2, SALL4, SOX2 and POU5F1) (Fig. 6). |
|
| Publications: |
1 |
| + |
IGF1 | up-regulates 
|
PPP3CC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235828 |
|
|
Mus musculus |
C2C12 Cell, Satellite Cell |
| pmid |
sentence |
| 10448861 |
Treatment with igf-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor nf-atc1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle, Myotube |
| Pathways: | IGF and Myogenesis |
| + |
IGF1 | up-regulates
|
Calcineurin |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252306 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10448861 |
Treatment with igf-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor nf-atc1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IGF1 | up-regulates activity
binding
|
IGF1R |
0.955 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175662 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Binding of IGF1 to its receptor leads to activation of its intrinsic tyrosine kinase and autophosphorylation, thus generating docking sites for insulin receptor substrate (IRS), which is also phosphorylated by the IGF1 receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, IGF and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma |
| + |
IGF1 | up-regulates
|
PPP3CB |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235825 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10448861 |
Treatment with igf-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor nf-atc1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | IGF and Myogenesis |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
IGF1 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251720 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10050749 |
Growth hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1α |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXA9 | up-regulates quantity by expression
transcriptional regulation
|
IGF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205308 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25252870 |
Hoxa9bound directly to the putative promoter and a dnase-hypersensitive region in the first intron of the igf1 gene. Transcription rates of the igf1 gene paralleledhoxa9activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
IGF1 | up-regulates
binding
|
IGF1R |
0.955 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182484 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19029956 |
At the cellular level, the ligands IGF1, IGF2 and insulin bind to various members of the insulin receptor (IR) - IGF1 receptor (IGF1R) family. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, IGF and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma |
| + |
IGF1 | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-23166 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2689937 |
Preadipocytes converted to adipocytes when insulin-like growth factor-1 or insulin was added to a medium depleted of those compounds |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IGF1 | up-regulates
|
PP2B |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269890 |
|
|
Mus musculus |
C2C12 Cell, Satellite Cell |
| pmid |
sentence |
| 10448861 |
Treatment with igf-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor nf-atc1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle, Myotube |
| + |
IGF1 | down-regulates activity 
binding
|
GSK3B/Axin/APC |
0.343 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227948 |
|
|
Homo sapiens |
Breast Cancer Cell, Kidney Cancer Cell |
| pmid |
sentence |
| 16039586 |
Erk, which is activated by hbx, associates with gsk-3beta through a docking motif ((291)fkfp) of gsk-3beta and phosphorylates gsk-3beta at the (43)thr residue, which primes gsk-3beta for its subsequent phosphorylation at ser9 by p90rsk, resulting in inactivation of gsk-3beta and upregulation of beta-catenin. This pathway is a general signal, as it was also observed in cell lines in which erk-primed inactivation of gsk-3beta was regulated by igf-1, tgf-beta, and receptor tyrosine kinase her2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IGF1 | up-regulates
|
PPP3CA |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235645 |
|
|
Mus musculus |
C2C12 Cell, Satellite Cell |
| pmid |
sentence |
| 10448861 |
Treatment with igf-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor nf-atc1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle, Myotube |
| Pathways: | IGF and Myogenesis |
| + |
IGF1 | up-regulates quantity by expression
transcriptional regulation
|
FBN1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251862 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 17200203 |
Decorin and IGF-I induce fibrillin-1 protein synthesis in normal rat kidney fibroblasts |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
IGF1 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256152 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217713 |
PGC-1 alpha specifically induces IGF1 and represses myostatin, and expression of PGC-1a 4 in vitro and in vivo induces robust skeletal muscle hypertrophy |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MIR1-1 | down-regulates quantity
post transcriptional regulation
|
IGF1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255793 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25477897 |
The down-regulation of miR-29b is thought to promote DNA hypermethylation in AML since miR-29b can directly target DNMT3A, DNMT3B, and Sp1 (a transcriptional regulator of DNMT1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
3.0
IGF1
- 
- 