| + |
PIM1 | up-regulates activity 
phosphorylation
|
NFATC1 |
0.629 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276779 |
Ser151 |
VLPSSKRsPSTATLS |
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 31730483 |
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276774 |
Ser153 |
PSSKRSPsTATLSLP |
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 31730483 |
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276770 |
Ser245 |
PSTSPRAsVTEESWL |
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 31730483 |
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276768 |
Ser256 |
ESWLGARsSRPASPC |
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 31730483 |
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276767 |
Ser257 |
SWLGARSsRPASPCN |
in vitro |
|
| pmid |
sentence |
| 31730483 |
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276769 |
Ser269 |
PCNKRKYsLNGRQPP |
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 31730483 |
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276776 |
Ser335 |
GDGVPVKsRKTTLEQ |
in vitro |
|
| pmid |
sentence |
| 31730483 |
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276777 |
Thr154 |
SSKRSPStATLSLPS |
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 31730483 |
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276775 |
Thr338 |
VPVKSRKtTLEQPPS |
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 31730483 |
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276771 |
Thr339 |
PVKSRKTtLEQPPSV |
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 31730483 |
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. |
|
| Publications: |
10 |
Organism: |
Homo Sapiens, In Vitro |
| + |
IKBKE | up-regulates activity
phosphorylation
|
NFATC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276778 |
Ser151 |
VLPSSKRsPSTATLS |
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 31730483 |
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates 
phosphorylation
|
NFATC1 |
0.606 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74560 |
Ser172 |
YRDPSCLsPASSLSS |
Homo sapiens |
|
| pmid |
sentence |
| 10652349 |
We show that jnk, erk, and p38 physically associate with the nfatc n-terminal regulatory domain and can directly phosphorylate functionally important residues involved in regulating nfatc subcellular localization, namely ser(172) and the conserved nfatc ser-pro repeats. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK10 | down-regulates
phosphorylation
|
NFATC1 |
0.425 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74556 |
Ser172 |
YRDPSCLsPASSLSS |
Homo sapiens |
|
| pmid |
sentence |
| 10652349 |
We show that jnk, erk, and p38 physically associate with the nfatc n-terminal regulatory domain and can directly phosphorylate functionally important residues involved in regulating nfatc subcellular localization, namely ser(172) and the conserved nfatc ser-pro repeats. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates
phosphorylation
|
NFATC1 |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74564 |
Ser172 |
YRDPSCLsPASSLSS |
Homo sapiens |
|
| pmid |
sentence |
| 10652349 |
We show that jnk, erk, and p38 physically associate with the nfatc n-terminal regulatory domain and can directly phosphorylate functionally important residues involved in regulating nfatc subcellular localization, namely ser(172) and the conserved nfatc ser-pro repeats. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates
phosphorylation
|
NFATC1 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93531 |
Ser245 |
PSTSPRAsVTEESWL |
Homo sapiens |
|
| pmid |
sentence |
| 12351631 |
Here we show that overexpression of pka causes phosphorylation and cytoplasmic accumulation of nf-atc1 in direct opposition to calcineurin by phosphorylating ser-245, ser-269, and ser-294 in the conserved serine-proline repeat domainwe further show that a complete block of nf-atc1 nuclear localization by pka requires a second kinase activity that can be supplied by glycogen synthase kinase-3 (gsk-3) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93535 |
Ser269 |
PCNKRKYsLNGRQPP |
Homo sapiens |
|
| pmid |
sentence |
| 12351631 |
Here we show that overexpression of pka causes phosphorylation and cytoplasmic accumulation of nf-atc1 in direct opposition to calcineurin by phosphorylating ser-245, ser-269, and ser-294 in the conserved serine-proline repeat domainwe further show that a complete block of nf-atc1 nuclear localization by pka requires a second kinase activity that can be supplied by glycogen synthase kinase-3 (gsk-3) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93539 |
Ser294 |
PHGSPRVsVTDDSWL |
Homo sapiens |
|
| pmid |
sentence |
| 12351631 |
Here we show that overexpression of pka causes phosphorylation and cytoplasmic accumulation of nf-atc1 in direct opposition to calcineurin by phosphorylating ser-245, ser-269, and ser-294 in the conserved serine-proline repeat domainwe further show that a complete block of nf-atc1 nuclear localization by pka requires a second kinase activity that can be supplied by glycogen synthase kinase-3 (gsk-3) |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PRKCA | down-regulates activity
phosphorylation
|
NFATC1 |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249175 |
Ser294 |
PHGSPRVsVTDDSWL |
Homo sapiens |
|
| pmid |
sentence |
| 12351631 |
Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1. | Here we show that overexpression of PKA causes phosphorylation and cytoplasmic accumulation of NF-ATc1 in direct opposition to calcineurin by phosphorylating Ser-245, Ser-269, and Ser-294 in the conserved serine-proline repeat domain, and that mutation of these serines blocks the effect of PKA. Activation of endogenous PKA is similarly able to promote phosphorylation of these sites on NF-ATc1 in two lymphoid cell lines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, T cell activation |
| + |
JAK3 | up-regulates activity
phosphorylation
|
NFATC1 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276435 |
Tyr371 |
ADFAPEDySSFQHIR |
Homo sapiens |
Thymocyte |
| pmid |
sentence |
| 23263556 |
Here we found that IL-7-Jak3 signals activated the transcription factor NFATc1 in DN thymocytes by phosphorylating Tyr371 in the regulatory region of NFATc1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP3CA | up-regulates
dephosphorylation
|
NFATC1 |
0.817 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176370 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21880741 |
Calcineurin directly dephosphorylates nfat resulting in the nuclear import of nfat. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84038 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 14722106 |
Once activated, calcineurin directly dephosphorylates NFAT proteins that are present in a hyperphosphorylated latent form in the cytoplasm and induces their rapid translocation into the nucleus, where in concert with nuclear partner proteins such as the AP-1 transcription factor complex, they are able to bind cooperatively to their target promoter elements and activate the transcription of specific NFAT target genes |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127248 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 15276472 |
Once activated, calcineurin directly dephosphorylates members of the nuclear factor of activated t-cells (nfat) transcription factor family in the cytoplasm, promoting their translocation into the nucleus. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
NFATC1 | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251730 |
|
|
Homo sapiens |
Smooth Muscle |
| pmid |
sentence |
| 17079331 |
The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway has been found to play a role in regulating growth and differentiation in several cell types. However, the functional significance of NFAT in the vasculature is largely unclear. Here we show that NFATc1, NFATc3, and NFATc4 are expressed in human myometrial arteries. |Chronic inhibition of NFAT significantly reduced IL-6 production in intact myometrial arteries and inhibited cell proliferation in vascular smooth muscle cells cultured from explants from the same arteries. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC1 | up-regulates 
transcriptional regulation
|
Myotube_hypertrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256215 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14729474 |
To summarize, these two studies have generated important insights into the control of skeletal muscle hypertrophy by the calcineurin/NFATc1 signaling pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
PP2B | up-regulates
relocalization
|
NFATC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269989 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
NFATC1 | up-regulates quantity by expression
transcriptional regulation
|
GPC6 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264022 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 21871017 |
NFAT transcriptionally regulates GPC6 induction in breast cancer cells and binds to three regulatory elements in the GPC6 proximal promoter. Expression of GPC6 in response to NFAT signalling promotes invasive migration, whereas GPC6 silencing with shRNA (small-hairpin RNA) potently blocks this phenotype. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIM2 | up-regulates activity
phosphorylation
|
NFATC1 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276772 |
|
|
in vitro |
|
| pmid |
sentence |
| 31730483 |
In addition to PIM1, also PIM2 and PIM3 were able to phosphorylate WT, but not MM NFATC1 in vitro (Fig. (Fig.22c). |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PPP3CC | up-regulates
relocalization
|
NFATC1 |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179796 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 18676376 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84053 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle, Skeletal Muscle |
| + |
NFATC1 | up-regulates quantity by expression
transcriptional regulation
|
IL2 |
0.583 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275405 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10022916 |
Together, our results demonstrate that dnNFAT inhibits the production of IL-2. Thus, the NFAT transcription factor contributes to the regulation of IL-2 gene expression and therefore plays a critical role in the initiation of immune responses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIM3 | up-regulates activity
phosphorylation
|
NFATC1 |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276773 |
|
|
in vitro |
|
| pmid |
sentence |
| 31730483 |
In addition to PIM1, also PIM2 and PIM3 were able to phosphorylate WT, but not MM NFATC1 in vitro (Fig. (Fig.22c). |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
NFATC1 | up-regulates quantity by expression
transcriptional regulation
|
PLAUR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253336 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23015147 |
Inducible podocyte-specific expression of constitutively active NFATc1 increased podocyte uPAR expression by binding to the Plaur gene promoter (encoding uPAR) in chromatin immunoprecipitation assays. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
PPP3CB | up-regulates
relocalization
|
NFATC1 |
0.711 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84047 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AP1 | up-regulates activity
binding
|
NFATC1 |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253004 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 15928679 |
Activator protein 1 (AP1) proteins are the main transcriptional partners of NFAT during T-cell activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, T cell activation |
| + |
PPP3CA | up-regulates activity
dephosphorylation
|
NFATC1 |
0.817 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253329 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23015147 |
Calcineurin is known to facilitate the nuclear translocation of the nuclear factor of activated T cells (NFAT). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
NFATC1 | up-regulates
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270537 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11163226 |
In this study, the roles of NFATc1 and NFATc2 in T and B cells were examined. These results further characterize NFAT as a transcription factor family that plays a critical role in the regulation of lymphocyte effector differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation |
| + |
CDC42 | up-regulates activity
|
NFATC1 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253370 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18976935 |
Furthermore, membrane targeting of the SLAT Dbl-homology (catalytic) domain was sufficient to trigger TCR-mediated NFAT activation and Th1 and Th2 differentiation in a Cdc42-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC1 | up-regulates quantity by expression
transcriptional regulation
|
IL4 |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254498 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8668213 |
Recombinant NFAT1 can mediate transcription of the interleukin-2, interleukin-4, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor promoters in T cells, suggesting that NFAT1 contributes to the CsA-sensitive transcription of these genes during the immune response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC1 | up-regulates quantity by expression
transcriptional regulation
|
MYH7 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251956 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 17111365 |
Transient transfection assays demonstrated that the calcineurin/NFATc1 signaling pathway is essential for MyHCbeta promoter activation during transformation of C2C12 myotubes but is not sufficient for complete fast MyHCIId/x promoter inhibition. Along with NFATc1, myocyte enhancer factor-2D (MEF-2D) and the myogenic transcription factor MyoD transactivated the MyHCbeta promoter in calcium-ionophore-treated myotubes in a calcineurin-dependent manner. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFATC1 | up-regulates activity
|
T_cell_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252344 |
|
|
|
|
| pmid |
sentence |
| 10358178 |
The transcription factor NF-ATc that controls gene expression in T lymphocytes and embryonic cardiac cells is expressed in three prominent isoforms. |
|
| Publications: |
1 |
| Pathways: | T cell activation |
| + |
NFATC1 | up-regulates quantity by expression
transcriptional regulation
|
PTGS2 |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264026 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21871017 |
NFAT induces the transcription of the COX2 (cyclo-oxygenase-2) gene incancer cells thereby enhancing invasive migration |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Calcineurin | up-regulates
dephosphorylation
|
NFATC1 |
0.821 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252313 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 14722106 |
Once activated, calcineurin directly dephosphorylates NFAT proteins that are present in a hyperphosphorylated latent form in the cytoplasm and induces their rapid translocation into the nucleus, where in concert with nuclear partner proteins such as the AP-1 transcription factor complex, they are able to bind cooperatively to their target promoter elements and activate the transcription of specific NFAT target genes |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252323 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21880741 |
Calcineurin directly dephosphorylates nfat resulting in the nuclear import of nfat. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, Focal segmental glomerulosclerosis, T cell activation |
3.0
NFATC1
- 
- 