| + |
HES1 | down-regulates quantity by repression 
transcriptional regulation
|
ASCL1 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254824 |
|
|
Homo sapiens |
Neuroblastoma Cell |
| pmid |
sentence |
| 11054669 |
Our data show that functional sympathetic neuronal differentiation of neuroblastoma cells is associated with transient activation of HES-1 and down-regulation of HASH-1 expression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265146 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 30030829 |
The basic-helixloop-helix factors HES1 and HES5 repress the expression of the proneural genes (Ascl1, Atoh1, Neurog1 and Neurog2) and thereby inhibit NSCs differentiation and neuron production |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | Retinoic acid Signaling |
| + |
HES5 | down-regulates quantity by repression
transcriptional regulation
|
ASCL1 |
0.551 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265147 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 30030829 |
The basic-helixloop-helix factors HES1 and HES5 repress the expression of the proneural genes (Ascl1, Atoh1, Neurog1 and Neurog2) and thereby inhibit NSCs differentiation and neuron production |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CHD8 | down-regulates quantity 
transcriptional regulation
|
ASCL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268914 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32839322 |
Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and Chd8−/− NPCs, and several other Sox TF members (Sox2, Sox7, and Sox11) became derepressed in the Chd8−/− cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ASCL1 | down-regulates quantity by repression
transcriptional regulation
|
DKK1 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245885 |
|
|
Mus musculus |
Glioblastoma Cell |
| pmid |
sentence |
| 23707066 |
We demonstrate that a critical factor in the set, ASCL1, activates Wnt signaling by repressing the negative regulator DKK1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
LMO3 | up-regulates quantity by expression 
transcriptional regulation
|
ASCL1 |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254825 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21573214 |
Overexpression of both LMO3 and HEN2 induced expression of Mash1, suggesting that they might function as a transcriptional activator for Mash1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DTX1 | down-regulates
binding
|
ASCL1 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110626 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11564735 |
Through its binding to p300, dtx1 inhibited transcriptional activation by the neural-specific helix-loop-helix-type transcription factor mash1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NHLH2 | up-regulates quantity by expression
transcriptional regulation
|
ASCL1 |
0.245 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254823 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21573214 |
Overexpression of both LMO3 and HEN2 induced expression of Mash1, suggesting that they might function as a transcriptional activator for Mash1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ASCL1 | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265174 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 24243019 |
Here we reveal a hierarchical mechanism in the direct conversion of fibroblasts into induced neuronal (iN) cells mediated by the transcription factors Ascl1|Accordingly, Ascl1-mutant mice show severe defects in neurogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| Pathways: | Retinoic acid Signaling |
3.0
ASCL1
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- 