Summary

Name DTX1
Full Name E3 ubiquitin-protein ligase DTX1
Synonyms Protein deltex-1, Deltex1, hDTX1
Primary ID Q86Y01
Links - -
Type protein
Relations 11
Pathways NOTCH Signaling, NOTCH Signaling and Myogenesis
Function Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

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Relations

Regulator Mechanism target score ℹ
+ HES1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DTX1 0.318
Publications: 1 Organism: Homo Sapiens
Tissue: Osteosarcoma Cell
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ DTX1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ERBB2 0.2
Publications: 1 Organism: Homo Sapiens
+ DTX1up-regulates activity img/direct-activation.png ubiquitination NOTCH1 0.773
Publications: 3 Organism: Mus Musculus, Drosophila Melanogaster, Homo Sapiens
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ ITCHdown-regulates img/direct_inhibition.png ubiquitination DTX1 0.688
Publications: 1 Organism: Homo Sapiens
+ DTX1up-regulates activity img/direct-activation.png ubiquitination NOTCH 0.773
Publications: 1 Organism: Drosophila Melanogaster
+ DTX1down-regulates img/direct_inhibition.png binding ASCL1 0.265
Publications: 1 Organism: Homo Sapiens
+ DTX1up-regulates img/direct-activation.png binding EP300 0.389
Publications: 1 Organism: Homo Sapiens
+ DTX1down-regulates img/indirect_inhibition.png TCF3 0.278
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination DTX1 0.2
Publications: 1 Organism: Homo Sapiens