| + |
TEF |
transcriptional regulation
|
NPPB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253652 |
|
|
|
|
| pmid |
sentence |
| 15837525 |
In comparison to the ANF gene, less is known about BNP promoter consensus elements that regulate gene expression by mechanical or neurohumoral agonists. A number of cis-acting elements for GATA, Nkx2.5, NF-kappaB and TEF transcription factors have recently been identified within the BNP promoter that regulate BNP expression in response to specific agonists. This review focuses on the information available regarding cis-acting determinants responsible for inducible BNP transcription. |
|
| Publications: |
1 |
| + |
NFKB1 |
transcriptional regulation
|
NPPB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253648 |
|
|
|
|
| pmid |
sentence |
| 15837525 |
In comparison to the ANF gene, less is known about BNP promoter consensus elements that regulate gene expression by mechanical or neurohumoral agonists. A number of cis-acting elements for GATA, Nkx2.5, NF-kappaB and TEF transcription factors have recently been identified within the BNP promoter that regulate BNP expression in response to specific agonists. This review focuses on the information available regarding cis-acting determinants responsible for inducible BNP transcription. |
|
| Publications: |
1 |
| + |
SHOX | up-regulates quantity by expression 
transcriptional regulation
|
NPPB |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255138 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17881654 |
The ability of SHOX to transactivate the NPPB endogenous promoter was demonstrated in luciferase reporter assays using serial deletions of the NPPB promotor region. Binding of SHOX to the NPPB promoter was also demonstrated in vivo by chromatin fixation and immunoprecipitation. We also demonstrate the lack of promoter activation in two SHOX mutants from patients with Leri-Weill syndrome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA |
transcriptional regulation
|
NPPB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253651 |
|
|
|
|
| pmid |
sentence |
| 15837525 |
In comparison to the ANF gene, less is known about BNP promoter consensus elements that regulate gene expression by mechanical or neurohumoral agonists. A number of cis-acting elements for GATA, Nkx2.5, NF-kappaB and TEF transcription factors have recently been identified within the BNP promoter that regulate BNP expression in response to specific agonists. This review focuses on the information available regarding cis-acting determinants responsible for inducible BNP transcription. |
|
| Publications: |
1 |
| + |
NKX2-5 |
transcriptional regulation
|
NPPB |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253649 |
|
|
|
|
| pmid |
sentence |
| 15837525 |
In comparison to the ANF gene, less is known about BNP promoter consensus elements that regulate gene expression by mechanical or neurohumoral agonists. A number of cis-acting elements for GATA, Nkx2.5, NF-kappaB and TEF transcription factors have recently been identified within the BNP promoter that regulate BNP expression in response to specific agonists. This review focuses on the information available regarding cis-acting determinants responsible for inducible BNP transcription. |
|
| Publications: |
1 |
| + |
XBP1 | up-regulates quantity by expression
transcriptional regulation
|
NPPB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255609 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20170659 |
The promoter assay with overexpression of sXBP1 or norepinephrine showed that the proximal AP1/CRE-like element in the promoter region of BNP was critical for transcriptional regulation of BNP by sXBP1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NPPB
- 
- 