Relation Results

Summary

Name MAP3K5
Full Name Mitogen-activated protein kinase kinase kinase 5
Synonyms Apoptosis signal-regulating kinase 1, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5 | ASK1, MAPKKK5, MEKK5
Primary ID Q99683
Links - -
Type protein
Relations 57
Pathways P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of ...
View More

Viewer

Type: Score: Layout: SPV 
0.8380.5890.4960.20.7210.6370.20.2830.20.2890.5810.6220.20.3280.4430.3220.5380.5890.3710.3720.7310.3240.20.5830.2510.8360.20.40.2550.6850.3730.70.6020.360.20.20.5380.2920.8380.36MAP3K5DAXXMAP2K3ZNF622PIMAKT1AKT2AKTPIM1RPS6KA3PP2Ca_R1A_Bd CDKN1AMAP2K4LRRK2PGAM5PPM1LMAP3K6PPP5CJAK2PTPN11TRAF2MAPK1CDONMAP2K7DUSP12DAB2IPCOX7A2LRAF1SLKFASSOD1ROSMAP2K6CDON/SPAG914-3-3HSPA2CDC25CSPAG9

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MAP3K5up-regulates img/direct-activation.png phosphorylation DAXX 0.838
Identifier Residue Sequence Organism Cell Line
SIGNOR-188321 Ser176 TNAENTAsQSPRTRG Homo sapiens
pmid sentence
Our data demonstrated that ask1 controls the cytoplasmic localization of daxx (fig.1). our results indicate that daxx not only activates ask1 but also is a downstream target of ask1 and that accumulated daxx further activates ask1. Thus, the daxx-ask1 positive feedback loop amplifying jnk/p38 signaling plays an important role in the cell-killing effects of stressors, such as tnfalpha.
Identifier Residue Sequence Organism Cell Line
SIGNOR-188325 Ser184 QSPRTRGsRRQIQRL Homo sapiens
pmid sentence
Our data demonstrated that ask1 controls the cytoplasmic localization of daxx (fig.1). our results indicate that daxx not only activates ask1 but also is a downstream target of ask1 and that accumulated daxx further activates ask1. Thus, the daxx-ask1 positive feedback loop amplifying jnk/p38 signaling plays an important role in the cell-killing effects of stressors, such as tnfalpha.
Publications: 2 Organism: Homo Sapiens
+ MAP3K5up-regulates quantity by stabilization img/direct-activation.png phosphorylation DAXX 0.838
Identifier Residue Sequence Organism Cell Line
SIGNOR-109680 Ser176 TNAENTAsQSPRTRG Homo sapiens HeLa Cell
pmid sentence
we show that TNFalpha treatment induces the accumulation of Daxx protein through ASK1 activation by preventing its proteasome-dependent degradation. ASK1 directly phosphorylates Daxx at Ser(176) and Ser(184) and Daxx is required for the sustained activation of JNK. Our results indicate that Daxx not only activates ASK1 but also is a downstream target of ASK1 and that accumulated Daxx further activates ASK1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-109684 Ser184 QSPRTRGsRRQIQRL Homo sapiens HeLa Cell
pmid sentence
we show that TNFalpha treatment induces the accumulation of Daxx protein through ASK1 activation by preventing its proteasome-dependent degradation. ASK1 directly phosphorylates Daxx at Ser(176) and Ser(184) and Daxx is required for the sustained activation of JNK. Our results indicate that Daxx not only activates ASK1 but also is a downstream target of ASK1 and that accumulated Daxx further activates ASK1.
Publications: 2 Organism: Homo Sapiens
+ MAP3K5up-regulates activity img/direct-activation.png phosphorylation MAP2K3 0.589
Identifier Residue Sequence Organism Cell Line
SIGNOR-161763 Ser218 ISGYLVDsVAKTMDA Homo sapiens
pmid sentence
Ask1 is a member of a mapkkk family and functions as an upstream kinase engaged in c-jun nh2-terminal kinase (jnk)/p38 signaling via the phosphorylation and activation of mapkks, such as mkk3, -4, -6, and -7
Identifier Residue Sequence Organism Cell Line
SIGNOR-226672 Chlorocebus aethiops COS Cell
pmid sentence
ASK1 activated SEK1 and MKK3 up to 7.0- and 11.8-fold, respectively
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
+ MAP3K5up-regulates img/direct-activation.png phosphorylation ZNF622 0.496
Identifier Residue Sequence Organism Cell Line
SIGNOR-175113 Ser314 WCNEKGKsFYSTEAV Homo sapiens
pmid sentence
Ask1 directly phosphorylated zpr9 at ser(314) and thr(318), suggesting that zpr9 can act as an ask1 substrate. Ask1-mediated phosphorylation of zpr9 at ser(314) and thr(318) was also responsible for zpr9-induced apoptosis.
Identifier Residue Sequence Organism Cell Line
SIGNOR-175117 Thr318 KGKSFYStEAVQAHM Homo sapiens
pmid sentence
Ask1 directly phosphorylated zpr9 at ser(314) and thr(318), suggesting that zpr9 can act as an ask1 substrate. Ask1-mediated phosphorylation of zpr9 at ser(314) and thr(318) was also responsible for zpr9-induced apoptosis.
Publications: 2 Organism: Homo Sapiens
+ PIMdown-regulates img/direct_inhibition.png phosphorylation MAP3K5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259410 Ser83 ATRGRGSsVGGGSRR Homo sapiens NCI-H1299 Cell
pmid sentence
Pim1 phosphorylates and negatively regulates ask1-mediated apoptosispim1 phosphorylation of ask1 on ser83 inhibited ask1-mediated c-jun n-terminal kinase phosphorylation
Publications: 1 Organism: Homo Sapiens
+ AKT1down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.721
Identifier Residue Sequence Organism Cell Line
SIGNOR-252465 Ser83 ATRGRGSsVGGGSRR Homo sapiens HEK-293 Cell
pmid sentence
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1 akt decreased ask1 kinase activity stimulated by both oxidative stress and overexpression in 293 cells by phosphorylating a consensus akt site at serine 83 of ask1.
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ AKT2down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.637
Identifier Residue Sequence Organism Cell Line
SIGNOR-100588 Ser83 ATRGRGSsVGGGSRR Homo sapiens Breast Cancer Cell
pmid sentence
Akt2 interacts with and phosphorylates ask1 at ser-83 resulting in inhibition of its kinase activity
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ AKTdown-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-104646 Ser83 ATRGRGSsVGGGSRR Homo sapiens HEK-293 Cell
pmid sentence
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1 akt decreased ask1 kinase activity stimulated by both oxidative stress and overexpression in 293 cells by phosphorylating a consensus akt site at serine 83 of ask1.
Publications: 1 Organism: Homo Sapiens
+ PIM1down-regulates img/direct_inhibition.png phosphorylation MAP3K5 0.283
Identifier Residue Sequence Organism Cell Line
SIGNOR-187905 Ser83 ATRGRGSsVGGGSRR Homo sapiens NCI-H1299 Cell
pmid sentence
Pim1 phosphorylates and negatively regulates ask1-mediated apoptosispim1 phosphorylation of ask1 on ser83 inhibited ask1-mediated c-jun n-terminal kinase phosphorylation
Publications: 1 Organism: Homo Sapiens
+ RPS6KA3down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276464 Ser83 ATRGRGSsVGGGSRR Homo sapiens HEK-293T Cell
pmid sentence
We provide evidence to show that RSK2 inhibits ASK1 by phosphorylating S83, T1109, and T1326 through a novel mechanism in which phospho-T1109/T1326 inhibits ATP binding to ASK1, while phospho-S83 attenuates ASK1 substrate MKK6 binding.
Identifier Residue Sequence Organism Cell Line
SIGNOR-276463 Thr1109 DRKIIATtLSKLKLE Homo sapiens HEK-293T Cell
pmid sentence
We provide evidence to show that RSK2 inhibits ASK1 by phosphorylating S83, T1109, and T1326 through a novel mechanism in which phospho-T1109/T1326 inhibits ATP binding to ASK1, while phospho-S83 attenuates ASK1 substrate MKK6 binding.
Identifier Residue Sequence Organism Cell Line
SIGNOR-276462 Thr1326 VNGADEDtISRFLAE Homo sapiens HEK-293T Cell
pmid sentence
We provide evidence to show that RSK2 inhibits ASK1 by phosphorylating S83, T1109, and T1326 through a novel mechanism in which phospho-T1109/T1326 inhibits ATP binding to ASK1, while phospho-S83 attenuates ASK1 substrate MKK6 binding.
Publications: 3 Organism: Homo Sapiens
+ PP2Ca_R1A_Bd up-regulates activity img/direct-activation.png dephosphorylation MAP3K5 0.289
Identifier Residue Sequence Organism Cell Line
SIGNOR-254756 Ser966 NEYLRSIsLPVPVLV Homo sapiens
pmid sentence
DAB2IP also mediates recruitment of PP2A to ASK1, binding both proteins through its C2 domain; this favors removal of the inhibitory S967 phosphorylation and further activation of ASK1
Publications: 1 Organism: Homo Sapiens
+ MAP3K5up-regulates img/direct-activation.png phosphorylation CDKN1A 0.581
Identifier Residue Sequence Organism Cell Line
SIGNOR-153440 Ser98 GGRRPGTsPALLQGT Homo sapiens
pmid sentence
P21cip1 is phosphorylated in vitro by both ask1 and jnk1 at s98. /phosphorylation of p21cip1 at s98, which in vivo appears to be regulated by ask1, may therefore mediate negative feedback in the ask1 signaling pathway.
Publications: 1 Organism: Homo Sapiens
+ MAP3K5up-regulates activity img/direct-activation.png phosphorylation MAP2K4 0.622
Identifier Residue Sequence Organism Cell Line
SIGNOR-45373 Thr261 LVDSIAKtRDAGCRP Homo sapiens
pmid sentence
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase)
Identifier Residue Sequence Organism Cell Line
SIGNOR-45366 Homo sapiens COS-7 Cell
pmid sentence
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively.
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
+ MAP3K5up-regulates activity img/direct-activation.png phosphorylation MAP3K5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-158423 Thr813 GDNVLINtYSGVLKI Homo sapiens
pmid sentence
Reporter gene assays showed that all three identified in vitro autophosphorylation sites (thr813, thr838, thr842) regulate ask1 signalingmutation of thr838 drastically reduced reporter gene activity when compared to unstimulated control levels. Interestingly, mutation of the other two sites also provided a significant reduction in ask1 function (figure 6a), suggesting that autophosphorylation at the residues thr842 and thr813 regulates ask1 signaling.
Identifier Residue Sequence Organism Cell Line
SIGNOR-158427 Thr838 GINPCTEtFTGTLQY Homo sapiens
pmid sentence
Reporter gene assays showed that all three identified in vitro autophosphorylation sites (thr813, thr838, thr842) regulate ask1 signalingmutation of thr838 drastically reduced reporter gene activity when compared to unstimulated control levels. Interestingly, mutation of the other two sites also provided a significant reduction in ask1 function (figure 6a), suggesting that autophosphorylation at the residues thr842 and thr813 regulates ask1 signaling.
Identifier Residue Sequence Organism Cell Line
SIGNOR-158431 Thr842 CTETFTGtLQYMAPE Homo sapiens
pmid sentence
Reporter gene assays showed that all three identified in vitro autophosphorylation sites (thr813, thr838, thr842) regulate ask1 signalingmutation of thr838 drastically reduced reporter gene activity when compared to unstimulated control levels. Interestingly, mutation of the other two sites also provided a significant reduction in ask1 function (figure 6a), suggesting that autophosphorylation at the residues thr842 and thr813 regulates ask1 signaling.
Publications: 3 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
+ LRRK2up-regulates activity img/direct-activation.png phosphorylation MAP3K5 0.328
Identifier Residue Sequence Organism Cell Line
SIGNOR-277251 Thr825 LKISDFGtSKRLAGI Homo sapiens HEK-293 Cell
pmid sentence
LRRK2 phosphorylated ASK1 at Thr832 that is adjacent to Thr845, which serves as an autophosphorylation site. 
Publications: 1 Organism: Homo Sapiens
+ PGAM5up-regulates activity img/direct-activation.png dephosphorylation MAP3K5 0.443
Identifier Residue Sequence Organism Cell Line
SIGNOR-277984 Thr838 GINPCTEtFTGTLQY Homo sapiens HEK-293 Cell
pmid sentence
PGAM5 Is a Protein Ser/Thr Phosphatase That Activates ASK1. PGAM5 Dephosphorylates ASK1. This dephosphorylation unleashes phosphorylation ofThr-838 in the kinase domain, with activation of ASK1.
Publications: 1 Organism: Homo Sapiens
+ PPM1Ldown-regulates img/direct_inhibition.png dephosphorylation MAP3K5 0.322
Identifier Residue Sequence Organism Cell Line
SIGNOR-154554 Thr838 GINPCTEtFTGTLQY Homo sapiens
pmid sentence
Exogenous pp2cepsilon associated with exogenous ask1 in hek-293 cells under non-stressed conditions, inactivating ask1 by decreasing thr845 phosphorylation
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ MAP3K6up-regulates quantity by stabilization img/direct-activation.png phosphorylation MAP3K5 0.538
Identifier Residue Sequence Organism Cell Line
SIGNOR-260832 Thr838 GINPCTEtFTGTLQY Homo sapiens
pmid sentence
ASK2 Activates ASK1 by Phosphorylation
Publications: 1 Organism: Homo Sapiens
+ MAP3K6up-regulates activity img/direct-activation.png phosphorylation MAP3K5 0.538
Identifier Residue Sequence Organism Cell Line
SIGNOR-260773 Thr838 GINPCTEtFTGTLQY Homo sapiens
pmid sentence
These results suggested that ASK2 activates ASK1 by direct phosphorylation of Thr838 of ASK1.
Publications: 1 Organism: Homo Sapiens
+ PPP5Cdown-regulates activity img/direct_inhibition.png dephosphorylation MAP3K5 0.589
Identifier Residue Sequence Organism Cell Line
SIGNOR-111301 Thr838 GINPCTEtFTGTLQY Homo sapiens HeLa Cell
pmid sentence
Pp5 directly dephosphorylated an essential phospho-threonine residue within the kinase domain of ask1 and thereby inactivated ask1 activity in vitro and in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-248540 Thr842 CTETFTGtLQYMAPE Mus musculus
pmid sentence
After exposure of cells to H2O2, ASK1 is transiently activated by autophosphorylation at Thr845. The protein then associates with PP5 (protein serine/threonine phosphatase 5), which inactivates ASK1 by dephosphorylation of Thr845.
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ JAK2down-regulates img/direct_inhibition.png phosphorylation MAP3K5 0.371
Identifier Residue Sequence Organism Cell Line
SIGNOR-184600 Tyr718 IPERDSRySQPLHEE Homo sapiens
pmid sentence
Previously we have shown that tyrosine 718 of ask1 when phosphorylated is critical for socs1 binding and socs1-mediated degradation of ask1we identified jak2 and shp2 as a tyr-718-specific kinase and phosphatase, respectively.
Publications: 1 Organism: Homo Sapiens
+ PTPN11up-regulates img/direct-activation.png dephosphorylation MAP3K5 0.372
Identifier Residue Sequence Organism Cell Line
SIGNOR-184604 Tyr718 IPERDSRySQPLHEE Homo sapiens
pmid sentence
Previously we have shown that tyrosine 718 of ask1 when phosphorylated is critical for socs1 binding and socs1-mediated degradation of ask1we identified jak2 and shp2 as a tyr-718-specific kinase and phosphatase, respectively.
Publications: 1 Organism: Homo Sapiens
+ JAK2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MAP3K5 0.371
Identifier Residue Sequence Organism Cell Line
SIGNOR-276145 Tyr718 IPERDSRySQPLHEE Homo sapiens Aorta Cell Line
pmid sentence
Furthermore, JAK2, but not JAK1, directly bound to and phosphorylated ASK1 at Tyr-718, leading to an enhanced association of ASK1 with SOCS1 and subsequent ASK1 degradation. 
Publications: 1 Organism: Homo Sapiens
+ TRAF2up-regulates activity img/direct-activation.png binding MAP3K5 0.731
Identifier Residue Sequence Organism Cell Line
SIGNOR-60747 Homo sapiens
pmid sentence
Traf2 is a strong activator of ask1
Identifier Residue Sequence Organism Cell Line
SIGNOR-75334 Homo sapiens
pmid sentence
Tnf receptor (tnfr) associated factor 2 (traf2), an adapter protein that couples tnfrs to the sapks and p38s, can activate ask1 in vivo and can interact in vivo with the amino- and carboxyl-terminal noncatalytic domains of the ask1 polypeptide
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling, TNF-alpha Signaling
+ MAPK1up-regulates img/indirect-activation.png MAP3K5 0.324
Identifier Residue Sequence Organism Cell Line
SIGNOR-146751 Homo sapiens Neutrophil
pmid sentence
The role of members of the arrestin family to mediate kinase activation is also a well-established phenomenon, including activation of members of the src family, erk1/2, and jnk3. Activation often includes the recruitment and interaction of arrestins with upstream mapks (ask1, mek3, mkk3, and mek kinase-2).
Publications: 1 Organism: Homo Sapiens
+ CDON img/unknown.png binding MAP3K5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-235551 Mus musculus C2C12 Cell, Myoblast, HEK-293T Cell
pmid sentence
Cdo and jlp interacted with ask1 or tak1 in 293t cells and c2c12 myoblasts
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ MAP3K5up-regulates img/direct-activation.png phosphorylation MAP2K7 0.583
Identifier Residue Sequence Organism Cell Line
SIGNOR-117264 Homo sapiens
pmid sentence
Activation of mkk7 by ask1
Identifier Residue Sequence Organism Cell Line
SIGNOR-161766 Homo sapiens
pmid sentence
Ask1 is a member of a mapkkk family and functions as an upstream kinase engaged in c-jun nh2-terminal kinase (jnk)/p38 signaling via the phosphorylation and activation of mapkks, such as mkk3, -4, -6, and -7
Publications: 2 Organism: Homo Sapiens
Pathways:TNF-alpha Signaling
+ DUSP12down-regulates activity img/direct_inhibition.png dephosphorylation MAP3K5 0.251
Identifier Residue Sequence Organism Cell Line
SIGNOR-277032 Homo sapiens
pmid sentence
Our study showed that DUSP12 inhibited ASK1-JNK activation and DUSP12 can directly bind to and dephosphorylate ASK1.
Publications: 1 Organism: Homo Sapiens
+ DAB2IPup-regulates activity img/direct-activation.png binding MAP3K5 0.836
Identifier Residue Sequence Organism Cell Line
SIGNOR-254748 Homo sapiens
pmid sentence
DAB2IP also mediates recruitment of PP2A to ASK1, binding both proteins through its C2 domain; this favors removal of the inhibitory S967 phosphorylation and further activation of ASK1
Publications: 1 Organism: Homo Sapiens
+ MAP3K5up-regulates activity img/direct-activation.png phosphorylation COX7A2L 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278341 Homo sapiens
pmid sentence
Phosphorylation of EB1 by ASK1 promotes the binding of EB1 to CLIP-170 and p150 glued.
Publications: 1 Organism: Homo Sapiens
+ MAP3K5up-regulates activity img/direct-activation.png phosphorylation MAP2K7 0.583
Identifier Residue Sequence Organism Cell Line
SIGNOR-274148 Homo sapiens HEK-293 Cell
pmid sentence
Upon TNFα stimulation, MEKK1, ASK1, and TAK1 phosphorylate and activate MKK7, which in turn activates JNK
Publications: 1 Organism: Homo Sapiens
Pathways:TNF-alpha Signaling
+ RAF1down-regulates img/direct_inhibition.png binding MAP3K5 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-109023 Homo sapiens
pmid sentence
Raf-1 interacts with the proapoptotic, stress-activated protein kinase ask1 (apoptosis signal-regulating kinase 1) in vitro and in vivo.
Publications: 1 Organism: Homo Sapiens
+ PTPN11up-regulates quantity by stabilization img/direct-activation.png dephosphorylation MAP3K5 0.372
Identifier Residue Sequence Organism Cell Line
SIGNOR-276144 Homo sapiens Aorta Cell Line
pmid sentence
In this study, we identified JAK2 and SHP2 as a Tyr-718-specific kinase and phosphatase, respectively.
Publications: 1 Organism: Homo Sapiens
+ SLKup-regulates img/direct-activation.png phosphorylation MAP3K5 0.255
Identifier Residue Sequence Organism Cell Line
SIGNOR-142665 Homo sapiens
pmid sentence
Induction of apoptosis by the ste20-like kinase slk, a germinal center kinase that activates apoptosis signal-regulating kinase and p38
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ FASup-regulates img/direct-activation.png binding MAP3K5 0.685
Identifier Residue Sequence Organism Cell Line
SIGNOR-109676 Homo sapiens
pmid sentence
Ask1 binds fas
Publications: 1 Organism: Homo Sapiens
+ SOD1up-regulates img/indirect-activation.png MAP3K5 0.373
Identifier Residue Sequence Organism Cell Line
SIGNOR-262789 Mus musculus NSC-34 Cell
pmid sentence
To investigate the role of ASK1 in the motor neurotoxicity by SOD1mut, we examined whether SOD1mut activates ASK1 as assessed by in vitro kinase assay. Expression of SOD1mut, but not SOD1wt, activated endogenous ASK1 (Fig. 4A, top panel). We next examined whether SOD1mut-induced ASK1 activation is mediated by ER stress.
Publications: 1 Organism: Mus Musculus
+ ROSup-regulates img/indirect-activation.png MAP3K5 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-226609 Homo sapiens
pmid sentence
TNF- but not Fas-induced apoptosis requires ROS-dependent activation of ASK1_JNK/p38 pathways. Thus, ASK1 is selectively required for TNF- and oxidative stress-induced sustained activations of JNK/p38 and apoptosis.
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ MAP3K5up-regulates activity img/direct-activation.png phosphorylation MAP2K6 0.602
Identifier Residue Sequence Organism Cell Line
SIGNOR-45353 Homo sapiens COS-7 Cell
pmid sentence
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively.
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ CDON/SPAG9 img/unknown.png binding MAP3K5 0.36
Identifier Residue Sequence Organism Cell Line
SIGNOR-235557 Mus musculus C2C12 Cell, Myoblast, HEK-293T Cell
pmid sentence
Cdo and jlp interacted with ask1 or tak1 in 293t cells and c2c12 myoblasts
Publications: 1 Organism: Mus Musculus
+ 14-3-3down-regulates img/direct_inhibition.png binding MAP3K5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-69408 Homo sapiens HeLa Cell
pmid sentence
14-3-3 may suppress ask1-induced cell death by directly inhibiting the catalytic activity of ask1.
Publications: 1 Organism: Homo Sapiens
+ HSPA2down-regulates img/direct_inhibition.png binding MAP3K5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-94565 Homo sapiens
pmid sentence
Coimmunoprecipitation analysis revealed a physical interaction between endogenous hsp72 and ask1 in nih 3t3 cells exposed to mild heat shock. Hsp72 blocked both the homo-oligomerization of ask1 and ask1-dependent apoptosis.
Publications: 1 Organism: Homo Sapiens
+ MAP3K5up-regulates quantity by stabilization img/direct-activation.png binding MAP3K6 0.538
Identifier Residue Sequence Organism Cell Line
SIGNOR-260831 Homo sapiens HEK-293 Cell
pmid sentence
C-terminal region of ASK1 binds to ASK2 and inhibits the degradation of ASK2
Publications: 1 Organism: Homo Sapiens
+ CDC25Cdown-regulates activity img/direct_inhibition.png dephosphorylation MAP3K5 0.292
Identifier Residue Sequence Organism Cell Line
SIGNOR-277100 Homo sapiens
pmid sentence
At the interval CDC25C inhibits ASK1, dephosphorylating pThr838 in its activation loop.|CDC25C dephosphorylates ASK1 to inhibit its activity during the interphase.
Publications: 1 Organism: Homo Sapiens
+ DAXXup-regulates img/direct-activation.png binding MAP3K5 0.838
Identifier Residue Sequence Organism Cell Line
SIGNOR-60164 Homo sapiens
pmid sentence
Daxx was found to activate the jnk kinase kinase ask1, and overexpression of a kinase-deficient ask1 mutant inhibited fas- and daxx-induced apoptosis and jnk activation.
Publications: 1 Organism: Homo Sapiens
+ SPAG9 img/unknown.png binding MAP3K5 0.36
Identifier Residue Sequence Organism Cell Line
SIGNOR-235545 Mus musculus C2C12 Cell, Myoblast, HEK-293T Cell
pmid sentence
Cdo and jlp interacted with ask1 or tak1 in 293t cells and c2c12 myoblasts
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
a simple tooltip