4.0
Summary
| Name |  ATXN1View Modifications |
| Full Name | Ataxin-1 |
| Synonyms | Spinocerebellar ataxia type 1 protein | ATX1, SCA1 |
| Primary ID | P54253 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT1 | up-regulates quantity by stabilization 
phosphorylation
|
ATXN1 | 0.41 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT | up-regulates quantity by stabilization
phosphorylation
|
ATXN1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MDM2 | down-regulates quantity by destabilization 
ubiquitination
|
ATXN1 | 0.335 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DZIP3 | down-regulates quantity by destabilization
polyubiquitination
|
ATXN1 | 0.482 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RPS6KA5 | up-regulates quantity by stabilization
phosphorylation
|
ATXN1 | 0.261 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STUB1 | down-regulates quantity by destabilization
ubiquitination
|
ATXN1 | 0.44 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATXN1 | up-regulates quantity by expression
transcriptional regulation
|
CDH1 | 0.344 |
| Publications: | 1 | Organism: | Homo Sapiens | |