| + |
RNF216 | down-regulates quantity by destabilization 
ubiquitination
|
TIRAP |
0.387 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271607 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16968706 |
Triad3A promotes proteolytic degradation of adapter proteins. A, Triad3A promotes down-regulation of TIRAP, TRIF, and RIP1 proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TIRAP | up-regulates activity 
binding
|
MYD88 |
0.635 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252063 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11544529 |
Here we describe a protein, Mal (MyD88-adapter-like), which joins MyD88 as a cytoplasmic TlR-domain-containing protein in the human genome. Mal activates NF-_B, Jun amino-terminal kinase and extracellular signal-regulated kinase-1 and -2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110215 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25948473 |
Stimulation of Toll-like receptor (TLR) 4 leads to the activation of both MyD88-dependent and MyD88-independent pathways through the recruitment of adaptors TIRAP/MyD88 and TRIF/TRAM, respectively. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, Innate Immune Response, Toll like receptors |
| + |
TLR4 | up-regulates activity
binding
|
TIRAP |
0.779 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252064 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11544529 |
Here we describe a protein, Mal (MyD88-adapter-like), which joins MyD88 as a cytoplasmic TlR-domain-containing protein in the human genome. Mal activates NF-_B, Jun amino-terminal kinase and extracellular signal-regulated kinase-1 and -2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR2 | up-regulates activity
binding
|
TIRAP |
0.726 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266745 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EBV infection |
| + |
TLR9 | up-regulates activity
binding
|
TIRAP |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266748 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EBV infection |
| + |
TLR4 | up-regulates
binding
|
TIRAP |
0.779 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110337 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11544529 |
Mal (myd88-adapter-like) is required for toll-like receptor-4 signal transduction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLRs | up-regulates activity
binding
|
TIRAP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216298 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20404851 |
These differences are explained by the discovery of TIR domaincontaining adaptor molecules, including MyD88, TIRAP (Mal), TRIF and TRAM, which are recruited by distinct TLRs and activate distinct signaling pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response, Toll like receptors |
| + |
TIRAP | up-regulates activity
binding
|
AGER |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280459 |
|
|
Homo sapiens |
HEK-293ET Cell |
| pmid |
sentence |
| 21829704 |
These results indicate that TIRAP functions as an essential adaptor protein for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CLIP1 | down-regulates activity
binding
|
TIRAP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280460 |
|
|
Homo sapiens |
HEK-293FT Cell |
| pmid |
sentence |
| 29222167 |
CLIP170 promotes ubiquitination and degradation of TIRAP |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TIRAP | up-regulates activity
binding
|
TRAF6 |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280461 |
|
|
Homo sapiens |
HEK-293T/17 Cell |
| pmid |
sentence |
| 19592497 |
Mal interaction with TRAF6 is required for NF-κB transactivation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, Innate Immune Response, Toll like receptors |
4.0
TIRAP
- 
- 