| + |
MYD88 | up-regulates activity 
binding
|
DHX36 |
0.504 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260956 |
|
|
Homo sapiens |
Dendritic Cell |
| pmid |
sentence |
| 20696886 |
We further showed that both DHX9 and DHX36 are localized within the cytosol and are directly bound to the Toll-interleukin receptor domain of MyD88 via their helicase-associated domain 2 and DUF domains. This study demonstrates that DHX9/DHX36 represent the MyD88-dependent DNA sensors in the cytosol of pDCs and suggests a much broader role for DHX helicases in viral sensing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYD88 | up-regulates activity
binding
|
TRAF3 |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256079 |
|
|
Mus musculus |
Myeloid Cell Line |
| pmid |
sentence |
| 16306937 |
Using MyD88 as a prototypical adaptor, we identified TNF receptor-associated factor 3 (TRAF3) as a new component of TIR signalling complexes that is recruited along with TRAF6. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE |
| + |
TLR9 | up-regulates activity
binding
|
MYD88 |
0.701 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266742 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EBV infection |
| + |
IL1RL1 | up-regulates activity
binding
|
MYD88 |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277704 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16286016 |
As shown in Figure 3D, MyD88, IRAK, IRAK4, and TRAF6 are all recruited to ST2 upon IL-33 stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR2 | up-regulates activity
binding
|
MYD88 |
0.659 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266740 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EBV infection |
| + |
IL1R1 | up-regulates activity
binding
|
MYD88 |
0.944 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67140 |
|
|
Homo sapiens |
EL-4 Cell |
| pmid |
sentence |
| 10217414 |
Interleukin-1 (il-1) stimulates the association of the il-1 receptor-associated protein kinase (irak) with the heterodimer of il-iri and il-iracp via the adapter protein myd88. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
| + |
MYD88 | up-regulates activity
binding
|
DHX9 |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260955 |
|
|
Homo sapiens |
Dendritic Cell |
| pmid |
sentence |
| 20696886 |
We further showed that both DHX9 and DHX36 are localized within the cytosol and are directly bound to the Toll-interleukin receptor domain of MyD88 via their helicase-associated domain 2 and DUF domains. This study demonstrates that DHX9/DHX36 represent the MyD88-dependent DNA sensors in the cytosol of pDCs and suggests a much broader role for DHX helicases in viral sensing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYD88 | up-regulates activity
binding
|
IRAK1 |
0.843 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67143 |
|
|
Mus musculus |
EL-4 Cell |
| pmid |
sentence |
| 10217414 |
Interleukin-1 (il-1) stimulates the association of the il-1 receptor-associated protein kinase (irak) with the heterodimer of il-iri and il-iracp via the adapter protein myd88. Myd88 binds to both irak (il-1 receptor-associated kinase) and the heterocomplex (the signaling complex) of the two receptor chains and thereby mediates the association of irak with the receptor. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Innate Immune Response, IL1 Signaling , Toll like receptors |
| + |
MYD88 | up-regulates activity
binding
|
TRAF6 |
0.92 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260160 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28404732 |
In innate immunity, nearly all Toll-like receptors (TLRs), as well as the receptors of the interleukin 1 (IL-1) family of cytokines, initiate signaling by recruiting the adaptor protein MyD88. This is followed by the interaction of IL-1-receptor (IL-R)-associated kinase 4 (IRAK4) with MyD88 and then the interaction of other IRAK family members with IRAK4, to form an oligomeric complex, termed the Myddosome (8, 9). IRAK1 and IRAK2 can then interact with TRAF6 (10, 11) and induce TRAF6 dimerization (12), which triggers the activation of its E3 ligase activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, Innate Immune Response, IL1 Signaling , Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors |
| + |
TLRs | up-regulates activity
binding
|
MYD88 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260151 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors |
| + |
TIRAP | up-regulates activity
binding
|
MYD88 |
0.619 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110215 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25948473 |
Stimulation of Toll-like receptor (TLR) 4 leads to the activation of both MyD88-dependent and MyD88-independent pathways through the recruitment of adaptors TIRAP/MyD88 and TRIF/TRAM, respectively. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252063 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11544529 |
Here we describe a protein, Mal (MyD88-adapter-like), which joins MyD88 as a cytoplasmic TlR-domain-containing protein in the human genome. Mal activates NF-_B, Jun amino-terminal kinase and extracellular signal-regulated kinase-1 and -2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, Innate Immune Response, Toll like receptors |
| + |
MYD88 | up-regulates activity
binding
|
IRAK4 |
0.945 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252097 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12297423 |
Signaling between MyD88 and TRAF6 is mediated by members of the IL-1R-associated kinase (IRAK) family; however, the exact function of each IRAK protein remains controversial. IRAK-1 is required for the optimal transduction of IL-1R- and TLR-mediated signals, but IRAK-1 can be replaced by other IRAKs. Surprisingly, gene targeting studies show that the newest IRAK protein, IRAK-4, has an essential role in mediating signals initiated by IL-1R and TLR engagement. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155385 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 17548806 |
St2825 interfered with recruitment of irak1 and irak4 by myd88, causing inhibition of il-1beta-mediated activation of nf-kappab transcriptional activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
| + |
TLR4 | up-regulates activity
binding
|
MYD88 |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252065 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22664090 |
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
MYD88
- 
- 