+ |
M | up-regulates activity
|
CASP9 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260202 |
|
|
Homo sapiens |
|
pmid |
sentence |
25271362 |
Taken together, our results demonstrated that expression of M-protein causes activation of both caspases 8 and 9 via the PKB/Akt signalling cascades. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS |
+ |
M | up-regulates activity
|
CASP8 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260201 |
|
|
Homo sapiens |
|
pmid |
sentence |
25271362 |
Taken together, our results demonstrated that expression of M-protein causes activation of both caspases 8 and 9 via the PKB/Akt signalling cascades. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS |
+ |
M | down-regulates activity
binding
|
IKK-complex |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260261 |
|
|
Chlorocebus aethiops |
|
pmid |
sentence |
17705188 |
Together, these results indicate that SARS-CoV M suppresses NF-kappaB activity probably through a direct interaction with IKKbeta, resulting in lower Cox-2 expression. |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
Pathways: | COVID-19 Causal Network, SARS-CoV INFLAMMATORY RESPONSE |
+ |
M | down-regulates activity
|
AKT |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260200 |
|
|
Homo sapiens |
HEK-293FT Cell |
pmid |
sentence |
25271362 |
Consistent with our previous result, we detected a reduced phosphorylated PKB/Akt level and diminished PKB/Akt activity in mammalian cells expressing M-protein. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV INFLAMMATORY RESPONSE |
+ |
M | up-regulates
|
Apoptosis |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260198 |
|
|
Homo sapiens |
Lung Fibroblast Cell Line |
pmid |
sentence |
16845612 |
Co-transfection of M and N enhances the induction of apoptosis by M or N alone, which also suggests that the structural proteins of SARS-CoV may play an important role not only in the process of invasion but also in the pathogenetic process in cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS |