Summary

Name 3a
Full Name Protein 3a
Synonyms Accessory protein 3a, Protein U274, Protein X1 |
Primary ID P59632
Links - -
Type protein
Relations 7
Pathways COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE
Function Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/indirect-activation.png CASP9 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ up-regulates activity img/indirect-activation.png CYCS 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ up-regulates activity img/indirect-activation.png MAPK14 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png NLRP3 inflammasome 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV INFLAMMATORY RESPONSE
+ down-regulates quantity img/indirect_inhibition.png IFNAR 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE
+ up-regulates activity img/indirect-activation.png p38 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION
+ up-regulates activity img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION