Summary

Name RAP1GDS1
Full Name Rap1 GTPase-GDP dissociation stimulator 1
Synonyms Exchange factor smgGDS, SMG GDS protein, SMG P21 stimulatory GDP/GTP exchange protein
Primary ID P52306
Links - -
Type protein
Relations 9
Function Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein (PubMed:1549351, PubMed:11948427). Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake (PubMed:24349085).

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Relations

Regulator Mechanism target score ℹ
+ RAP1GDS1up-regulates img/direct-activation.png binding RHOA 0.616
Publications: 1 Organism: Homo Sapiens
+ RAP1GDS1up-regulates img/direct-activation.png binding KRAS 0.426
Publications: 1 Organism: Homo Sapiens
+ RAP1GDS1up-regulates img/direct-activation.png binding CDC42 0.292
Publications: 1 Organism: Homo Sapiens
+ RAP1GDS1up-regulates img/direct-activation.png binding RAP1B 0.423
Publications: 1 Organism: Homo Sapiens
+ RAP1GDS1up-regulates img/direct-activation.png binding RAP1A 0.43
Publications: 1 Organism: Homo Sapiens
+ RAP1GDS1up-regulates img/direct-activation.png binding RAC2 0.513
Publications: 1 Organism: Homo Sapiens
+ RAP1GDS1up-regulates img/direct-activation.png binding RHOC 0.303
Publications: 1 Organism: Homo Sapiens
+ RAP1GDS1up-regulates img/direct-activation.png binding RAC1 0.461
Publications: 1 Organism: Homo Sapiens
+ RAP1GDS1up-regulates img/direct-activation.png binding RHOB 0.283
Publications: 1 Organism: Homo Sapiens