3.0
Summary
| Name |  KDM5CView Modifications |
| Full Name | Lysine-specific demethylase 5C |
| Synonyms | Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, Protein SmcX, Protein Xe169 | DXS1272E, JARID1C, SMCX, XE169 |
| Primary ID | P41229 |
| Links |  -  -  |
| Type | protein |
| Relations | 13 |
| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | KDM5C | up-regulates activity 
demethylation
|
H3C1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM5C | up-regulates activity
demethylation
|
H3-4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM5C | down-regulates quantity by repression 
transcriptional regulation
|
PTEN | 0.347 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EPAS1 | up-regulates quantity by expression
transcriptional regulation
|
KDM5C | 0.284 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BRD4 | up-regulates quantity by expression 
transcriptional regulation
|
KDM5C | 0.336 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM5C | down-regulates quantity by repression
transcriptional regulation
|
SCN2A | 0.34 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | KDM5C | down-regulates quantity by repression
transcriptional regulation
|
SYN1 | 0.357 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | KDM5C | down-regulates quantity by repression
transcriptional regulation
|
BDNF | 0.28 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | KDM5C | up-regulates activity
demethylation
|
Histone H3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HIF1A | up-regulates quantity by expression
transcriptional regulation
|
KDM5C | 0.263 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 2-oxoglutarate(2-) | up-regulates activity
chemical activation
|
KDM5C | 0.8 |
| Publications: | 1 | |||
| + | CNOT4 | down-regulates quantity by destabilization 
ubiquitination
|
KDM5C | 0.566 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF4 | up-regulates activity
sumoylation
|
KDM5C | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |