Summary

Name MST1R
Full Name Macrophage-stimulating protein receptor
Synonyms MSP receptor, CDw136, Protein-tyrosine kinase 8, p185-Ron | PTK8, RON
Primary ID Q04912
Links - -
Type protein
Relations 7
Inhibitors MK-2461; N-[[3-fluoro-4-[[2-(1-methyl-4-imidazolyl)-7-thieno[3,2-b]pyridinyl]oxy]anilino]-sulfanylidenemethyl]-2-phenylacetamide; N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-3-pyridinecarboxamide
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ AKTup-regulates img/direct-activation.png phosphorylation MST1R 0.2
Publications: 1 Organism: Homo Sapiens
+ AKT1up-regulates img/direct-activation.png phosphorylation MST1R 0.54
Publications: 1 Organism: Homo Sapiens
+ MST1Rup-regulates activity img/direct-activation.png phosphorylation ABL1 0.276
Publications: 1
+ MK-2461down-regulates img/direct_inhibition.png chemical inhibition MST1R 0.8
Publications: 1 Organism: Homo Sapiens
+ N-[[3-fluoro-4-[[2-(1-methyl-4-imidazolyl)-7-thieno[3,2-b]pyridinyl]oxy]anilino]-sulfanylidenemethyl]-2-phenylacetamidedown-regulates img/direct_inhibition.png chemical inhibition MST1R 0.8
Publications: 1 Organism: Homo Sapiens
+ N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-3-pyridinecarboxamidedown-regulates img/direct_inhibition.png chemical inhibition MST1R 0.8
Publications: 1 Organism: Homo Sapiens
+ MST1up-regulates img/direct-activation.png binding MST1R 0.892
Publications: 1 Organism: Homo Sapiens