Summary

Name ZBTB16
Full Name Zinc finger and BTB domain-containing protein 16
Synonyms Promyelocytic leukemia zinc finger protein, Zinc finger protein 145, Zinc finger protein PLZF | PLZF, ZNF145
Primary ID Q05516
Links - -
Type protein
Relations 9
Pathways Acute Myeloid Leukemia, FLT3-ITD in AML, Satellite: miRNA network
Function Acts as a transcriptional repressor (PubMed:24359566). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ CDK2down-regulates img/direct_inhibition.png phosphorylation ZBTB16 0.286
Publications: 2 Organism: Homo Sapiens
+ ZBTB16up-regulates quantity by expression img/direct-activation.png transcriptional regulation RSAD2 0.2
Publications: 1 Organism: Homo Sapiens
+ FLT3down-regulates activity img/indirect_inhibition.png ZBTB16 0.32
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ ZBTB16down-regulates img/indirect_inhibition.png Proliferation 0.7
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ ZBTB16down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation miR-146a 0.4
Publications: 1 Organism: Homo Sapiens
+ ZBTB16form complex img/form-complex.png binding ZBTB16/ZBTB32 0.368
Publications: 1 Organism: Homo Sapiens
+ ZBTB16up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ KDM6Aup-regulates quantity by expression img/direct-activation.png transcriptional regulation ZBTB16 0.316
Publications: 1 Organism: Homo Sapiens