4.0
Summary
| Name |  ZBTB16View Modifications |
| Full Name | Zinc finger and BTB domain-containing protein 16 |
| Synonyms | Promyelocytic leukemia zinc finger protein, Zinc finger protein 145, Zinc finger protein PLZF | PLZF, ZNF145 |
| Primary ID | Q05516 |
| Links |  -  -  |
| Type | protein |
| Relations | 11 |
| Pathways | Acute Myeloid Leukemia, FLT3-ITD in AML, Satellite: miRNA network |
| Function | Acts as a transcriptional repressor (PubMed:24359566). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GSK3B | up-regulates activity 
phosphorylation
|
ZBTB16 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia | |||
| + | CDK2 | down-regulates 
phosphorylation
|
ZBTB16 | 0.282 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | ZBTB16 | form complex 
binding
|
ZBTB16/ZBTB32 | 0.359 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ZBTB16 | down-regulates quantity by repression
transcriptional regulation
|
miR-146a | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM6A | up-regulates quantity by expression
transcriptional regulation
|
ZBTB16 | 0.31 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ZBTB16 | up-regulates 
|
Apoptosis | 0.7 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML | |||
| + | FLT3 | down-regulates activity 
|
ZBTB16 | 0.314 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML | |||
| + | ZBTB16 | up-regulates quantity by expression
transcriptional regulation
|
RSAD2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ZBTB16 | down-regulates
|
Proliferation | 0.7 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML | |||