+ |
PKA | up-regulates activity
phosphorylation
|
CDK18 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264559 |
Ser14 |
KNFKRRFsLSVPRTE |
|
|
pmid |
sentence |
28361970 |
We previously revealed that PCTK3 is activated by two pathways: interaction with cytoplasmic cyclin A and phosphorylation at Ser-12 by protein kinase A (PKA)12. Activated PCTK3 phosphorylates retinoblastoma protein (Rb) in vitro. |
|
Publications: |
1 |
+ |
PRKACA | up-regulates activity
phosphorylation
|
CDK18 |
0.227 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264560 |
Ser14 |
KNFKRRFsLSVPRTE |
|
|
pmid |
sentence |
28361970 |
We previously revealed that PCTK3 is activated by two pathways: interaction with cytoplasmic cyclin A and phosphorylation at Ser-12 by protein kinase A (PKA)12. Activated PCTK3 phosphorylates retinoblastoma protein (Rb) in vitro. |
|
Publications: |
1 |
+ |
CDK18 | down-regulates quantity by destabilization
phosphorylation
|
AQP2 |
0.263 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264562 |
Ser261 |
RQSVELHsPQSLPRG |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
32164329 |
CDK18 controls AQP2 through phosphorylation at serine 261 and STUB1-mediated ubiquitination. |We had previously observed that a decrease in the phosphorylation of AQP2 at S261 is associated with a decrease in its poly-ubiquitination and an increase in its abundance |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CDK18 |
phosphorylation
|
RB1 |
0.291 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264558 |
|
|
in vitro |
|
pmid |
sentence |
28361970 |
Activated PCTK3 phosphorylates retinoblastoma protein (Rb) in vitro. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
CDK18 | form complex
binding
|
CyclinA2/CDK18 |
0.401 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273436 |
|
|
|
|
pmid |
sentence |
33781185 |
PCTAIRE kinases (PCTKs) are a CDK subfamily, characterized by serine to cysteine mutation in the consensus PSTAIRE motif, involved in binding to the cyclin. One member of this class is PCTK3, which has two isoforms (a and b) and is also known as CDK18. After being activated by cyclin A2 or phosphorylation at Ser12 by PKA, PCTK3 can perform several functions. |
|
Publications: |
1 |
+ |
CDK18 | down-regulates activity
|
PTK2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264561 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
28361970 |
PCTK3/CDK18 regulates cell migration and adhesion by negatively modulating FAK activity |
|
Publications: |
1 |
Organism: |
Homo Sapiens |