| + |
RB1 | up-regulates 
|
Cell_cycle_block |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245486 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21524151 |
Consistent with this, the magnitude of the response (i.e. the fraction of cells undergoing arrest) appears to diminish the closer the cells are to the time of S-phase entry. The existence of a time gap between full pRb phosphorylation and S-phase entry is also consistent with the notion that E2F, once released from pRb, transcriptionally activates factors needed for S-phase entry, a process which likely requires a significant amount of time. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer |
| + |
FOXO3 | up-regulates
|
Cell_cycle_block |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217881 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer |
| + |
BRCA1 | up-regulates
|
Cell_cycle_block |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251499 |
|
|
|
|
| pmid |
sentence |
| 15549093 |
The BRCA1 protein also contributes to cell-cycle arrest and DNA repair by homologous recombination |
|
| Publications: |
1 |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
7a | up-regulates
|
Cell_cycle_block |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260207 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16303160 |
Expression of SARS-CoV ORF7a block cell cycle arrest in G0/G1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKN1B | up-regulates
|
Cell_cycle_block |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178278 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18423396 |
Moreover, expression of p27(kip1), an inhibitor of the cell cycle, was down regulated in an akt1/pkbalpha-specific manner during adipocytedifferentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition |
| + |
SIRT1 | up-regulates
|
Cell_cycle_block |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217878 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKN1A | up-regulates
|
Cell_cycle_block |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267286 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24470334 |
The cell cycle regulator p21 is induced early in myoblast differentiation and functions to block cell cycle progression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer |
| + |
RBL2 | up-regulates
|
Cell_cycle_block |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267287 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10801445 |
Although forced expression of either p130 or pRb in mouse C2 myoblasts efficiently blocked cell cycle progression, only p130 inhibited the differentiation program. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
Cell_cycle_block