| + |
Gluconeogenesis | up-regulates 
|
α-D-glucose |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis |
| + |
PPARGC1A | up-regulates 
|
Gluconeogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209932 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20640476 |
However, in contrast to the role of AMPK, most reports to date indicate that PGC-1a induces gluconeogenesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Circadian clock |
| + |
3,3',5'-triiodothyronine | up-regulates
|
Gluconeogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267490 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24692351 |
It has been previously established that T3 stimulates gluconeogenesis, especially in the hyperthyroid state, and that hypothyroidism is associated with reduced gluconeogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| + |
DBP | up-regulates
|
Gluconeogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268028 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21633182 |
In addition to NHRs, Dbp, a known clock target gene, regulates expression of key metabolic genes involved in gluconeogenesis and lipogenesis (60). Because DBP levels change 100-fold in response to CLOCK/BMAL1 activation, it is conceivable that DBP generates circadian oscillation in metabolic processes such as gluconeogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
4.0
Gluconeogenesis