| + |
Aldolase | up-regulates quantity 
chemical modification
|
D-glyceraldehyde 3-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266482 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Aldolase catalyzes the reversible conversion of FBP to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate (DHAP; Figure 1). Aldolase is a tetramer of identical subunits of 40 kDa each, and 3 distinct isoenzymes have been identified: aldolase A, B, and C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
ZNF224 | down-regulates quantity by repression 
transcriptional regulation
|
Aldolase |
0.514 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270227 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17900823 |
We previously reported that ZNF224, a novel Krüppel-associated box-containing zinc-finger protein, represses aldolase A gene transcription by interacting with the KAP-1 co-repressor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM28 | down-regulates quantity by repression
transcriptional regulation
|
Aldolase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270228 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17900823 |
We previously reported that ZNF224, a novel Krüppel-associated box-containing zinc-finger protein, represses aldolase A gene transcription by interacting with the KAP-1 co-repressor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA1 | up-regulates quantity by expression 
transcriptional regulation
|
Aldolase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270223 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates quantity by expression
transcriptional regulation
|
Aldolase |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270229 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8955077 |
we characterize hypoxia response elements in the promoters of the ALDA, ENO1, and Ldha genes. Our data establish that functional hypoxia-response elements consist of a pair of contiguous transcription factor binding sites at least one of which contains the core sequence 5'-RCGTG-3' and is recognized by HIF-1. These results provide further evidence that the coordinate transcriptional activation of genes encoding glycolytic enzymes which occurs in hypoxic cells is mediated by HIF-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DBP | up-regulates quantity by expression
transcriptional regulation
|
Aldolase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270225 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 8383844 |
Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Aldolase | down-regulates quantity 
chemical modification
|
beta-D-fructofuranose 1,6-bisphosphate(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266490 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Aldolase catalyzes the reversible conversion of FBP to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate (DHAP; Figure 1). Aldolase is a tetramer of identical subunits of 40 kDa each, and 3 distinct isoenzymes have been identified: aldolase A, B, and C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HNF1A | up-regulates quantity by expression
transcriptional regulation
|
Aldolase |
0.32 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270224 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 8383844 |
Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Aldolase | up-regulates quantity
chemical modification
|
glycerone phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266486 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Aldolase catalyzes the reversible conversion of FBP to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate (DHAP; Figure 1). Aldolase is a tetramer of identical subunits of 40 kDa each, and 3 distinct isoenzymes have been identified: aldolase A, B, and C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
Aldolase |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270226 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Aldolase