| + |
MAPK1 | down-regulates 
phosphorylation
|
TFCP2 |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184168 |
Ser291 |
TYVNNSPsPGFNSSH |
Homo sapiens |
|
| pmid |
sentence |
| 19237534 |
We previously established that phosphorylation of lsf in early g1 at ser-291 and ser-309 inhibits its transcriptional activity and that dephosphorylation later in g1 is required for its reactivation. At the peak activities of erk and cyclin c/cdk2 in early g1, lsf is efficiently phosphorylated on ser-291 and ser-309. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184172 |
Ser309 |
SLGEGNGsPNHQPEP |
Homo sapiens |
|
| pmid |
sentence |
| 19237534 |
We previously established that phosphorylation of lsf in early g1 at ser-291 and ser-309 inhibits its transcriptional activity and that dephosphorylation later in g1 is required for its reactivation. At the peak activities of erk and cyclin c/cdk2 in early g1, lsf is efficiently phosphorylated on ser-291 and ser-309. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PPP2CA | up-regulates 
dephosphorylation
|
TFCP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167385 |
Ser291 |
TYVNNSPsPGFNSSH |
Homo sapiens |
|
| pmid |
sentence |
| 20682773 |
We previously established that phosphorylation of lsf in early g1 at ser-291 and ser-309 inhibits its transcriptional activity and that dephosphorylation later in g1 is required for its reactivation. This predominant cis conformation would also limit dephosphorylation of ser-291 and ser-309 by phosphatases such as pp2a |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167389 |
Ser309 |
SLGEGNGsPNHQPEP |
Homo sapiens |
|
| pmid |
sentence |
| 20682773 |
We previously established that phosphorylation of lsf in early g1 at ser-291 and ser-309 inhibits its transcriptional activity and that dephosphorylation later in g1 is required for its reactivation. This predominant cis conformation would also limit dephosphorylation of ser-291 and ser-309 by phosphatases such as pp2a |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates
phosphorylation
|
TFCP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184176 |
Ser291 |
TYVNNSPsPGFNSSH |
Homo sapiens |
|
| pmid |
sentence |
| 19237534 |
We previously established that phosphorylation of lsf in early g1 at ser-291 and ser-309 inhibits its transcriptional activity and that dephosphorylation later in g1 is required for its reactivation. At the peak activities of erk and cyclin c/cdk2 in early g1, lsf is efficiently phosphorylated on ser-291 and ser-309. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184180 |
Ser309 |
SLGEGNGsPNHQPEP |
Homo sapiens |
|
| pmid |
sentence |
| 19237534 |
We previously established that phosphorylation of lsf in early g1 at ser-291 and ser-309 inhibits its transcriptional activity and that dephosphorylation later in g1 is required for its reactivation. At the peak activities of erk and cyclin c/cdk2 in early g1, lsf is efficiently phosphorylated on ser-291 and ser-309. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDK3 | down-regulates
phosphorylation
|
TFCP2 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184164 |
Ser309 |
SLGEGNGsPNHQPEP |
Homo sapiens |
|
| pmid |
sentence |
| 19237534 |
In vitro, lsf is phosphorylated by cyclin e/cyclin-dependent kinase 2 (cdk2), cyclin c/cdk2, and cyclin c/cdk3, predominantly on s309. Phosphorylation by cyclin c/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of lsf during g1 progression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinC/CDK3 | down-regulates activity
phosphorylation
|
TFCP2 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273180 |
Ser309 |
SLGEGNGsPNHQPEP |
Homo sapiens |
|
| pmid |
sentence |
| 19237534 |
In vitro, lsf is phosphorylated by cyclin e/cyclin-dependent kinase 2 (cdk2), cyclin c/cdk2, and cyclin c/cdk3, predominantly on s309. Phosphorylation by cyclin c/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of lsf during g1 progression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinE/CDK2 | down-regulates
phosphorylation
|
TFCP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216713 |
Ser309 |
SLGEGNGsPNHQPEP |
Homo sapiens |
|
| pmid |
sentence |
| 19237534 |
In vitro, lsf is phosphorylated by cyclin e/cyclin-dependent kinase 2 (cdk2), cyclin c/cdk2, and cyclin c/cdk3, predominantly on s309. Phosphorylation by cyclin c/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of lsf during g1 progression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 | down-regulates
phosphorylation
|
TFCP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184160 |
Ser309 |
SLGEGNGsPNHQPEP |
Homo sapiens |
|
| pmid |
sentence |
| 19237534 |
In vitro, lsf is phosphorylated by cyclin e/cyclin-dependent kinase 2 (cdk2), cyclin c/cdk2, and cyclin c/cdk3, predominantly on s309. Phosphorylation by cyclin c/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of lsf during g1 progression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | down-regulates
phosphorylation
|
TFCP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270110 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19237534 |
We previously established that phosphorylation of lsf in early g1 at ser-291 and ser-309 inhibits its transcriptional activity and that dephosphorylation later in g1 is required for its reactivation. At the peak activities of erk and cyclin c/cdk2 in early g1, lsf is efficiently phosphorylated on ser-291 and ser-309. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | down-regulates
phosphorylation
|
TFCP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270201 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19237534 |
We previously established that phosphorylation of lsf in early g1 at ser-291 and ser-309 inhibits its transcriptional activity and that dephosphorylation later in g1 is required for its reactivation. At the peak activities of erk and cyclin c/cdk2 in early g1, lsf is efficiently phosphorylated on ser-291 and ser-309. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFCP2 | up-regulates quantity by expression 
transcriptional regulation
|
TF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255429 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20796026 |
Ectopic expression of CP2 led to increased transferrin expression at both the mRNA and protein levels, whereas knockdown of CP2 down-regulated transferrin mRNA and protein expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TFCP2
- 
- 