Summary

Name KLF10
Full Name Krueppel-like factor 10
Synonyms EGR-alpha, Transforming growth factor-beta-inducible early growth response protein 1, TGFB-inducible early growth response protein 1, TIEG-1 | TIEG, TIEG1
Primary ID Q13118
Links - -
Type protein
Relations 3
Function Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation KLF10 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SIN3A 0.46
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TGFBI 0.245
Publications: 1 Organism: Homo Sapiens