3.0
Summary
| Name |  KLF10View Modifications |
| Full Name | Krueppel-like factor 10 |
| Synonyms | EGR-alpha, Transforming growth factor-beta-inducible early growth response protein 1, TGFB-inducible early growth response protein 1, TIEG-1 | TIEG, TIEG1 |
| Primary ID | Q13118 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RAF1 | down-regulates quantity by destabilization 
phosphorylation
|
KLF10 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KLF10 | up-regulates activity 
binding
|
SIN3A | 0.458 |
| Publications: | 1 | Organism: | Cricetulus Griseus | |
| + | KLF10 | up-regulates quantity by expression
transcriptional regulation
|
TGFBI | 0.244 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VHL | down-regulates quantity by repression 
transcriptional regulation
|
KLF10 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PIN1 | down-regulates quantity by destabilization
binding
|
KLF10 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |