Name SNW1
Full Name SNW domain-containing protein 1
Synonyms Nuclear protein SkiP, Nuclear receptor coactivator NCoA-62, Ski-interacting protein | SKIIP, SKIP
Primary ID Q13573
Links - -
Type protein
Relations 8
Function Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.



Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding SNW1 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding SNW1 0.48
Publications: 2 Organism: Bacteriovorax Stolpii, Homo Sapiens
+ up-regulates img/direct-activation.png binding SNW1 0.14
Publications: 1 Organism: Bacteriovorax Stolpii
+ up-regulates img/direct-activation.png binding NOTCH1 0.65
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/direct_inhibition.png binding NCOR2 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.65
Publications: 1 Organism: In Vitro