Summary

Name SNW1
Full Name SNW domain-containing protein 1
Synonyms Nuclear protein SkiP, Nuclear receptor coactivator NCoA-62, Ski-interacting protein | SKIIP, SKIP
Primary ID Q13573
Links - -
Type protein
Relations 8
Pathways Acute Myeloid Leukemia, FLT3-ITD in AML
Function Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD.

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Relations

Regulator Mechanism target score ℹ
+ SNW1up-regulates img/direct-activation.png binding NOTCH1 0.603
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ NCOR2up-regulates img/direct-activation.png binding SNW1 0.593
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ NOTCH1up-regulates img/direct-activation.png binding SNW1 0.603
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ SNW1down-regulates img/direct_inhibition.png binding NCOR2 0.593
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ SNW1up-regulates activity img/direct-activation.png binding NOTCH1 0.603
Publications: 1 Organism: In Vitro
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ NOTCHup-regulates img/direct-activation.png binding SNW1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML