| + |
BMP4 | up-regulates 
binding
|
BMPR2 |
0.772 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-30697 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7673243 |
We have isolated a cdna encoding a novel transmembrane serine/threonine kinase from human skin fibroblasts which we demonstrate here to be a type ii receptor that binds bmp-4. This receptor (brk-3) is distantly related to other known type ii receptors and is distinguished from them by an extremely long carboxyl-terminal sequence following the intracellular kinase domain. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-35763 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8006002 |
Bmp-4 bound to alk-3 and alk-6 efficiently |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NOG | down-regulates activity 
binding
|
BMPR2 |
0.572 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219225 |
|
|
Gallus gallus |
|
| pmid |
sentence |
| 12478285 |
Noggin binds the domain that is re-quired for bmp-7 to interact with bmp type i and type ii receptors (PMID 22298955). Noggin Inhibits bmp by blocking the molecular interfaces of the binding epitopes for both type i and type ii receptors |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195612 |
|
|
Homo sapiens |
Osteoblast |
| pmid |
sentence |
| 22298955 |
Noggin binds the domain that is re-quired for bmp-7 to interact with bmp type i and type ii receptors.Noggin Inhibits bmp by blocking the molecular interfaces of the binding epitopes for both type i and type ii receptors (pmid 12478285) |
|
| Publications: |
2 |
Organism: |
Gallus Gallus, Homo Sapiens |
| Tissue: |
Bone |
| + |
GDF6 | up-regulates
binding
|
BMPR2 |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139093 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16049014 |
We found that transfection of small hairpin rna for bmprii and actriia in mc3t3 cells suppressed the signaling of gdf6, gdf7, and bmp10. Thus, the present approach provides a genomic paradigm for matching paralogous polypeptide ligands with a limited number of evolutionarily related receptors capable of activating specific downstream smad proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates
binding
|
BMPR2 |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-30512 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7644468 |
In transfected cos-1 cells, osteogenic protein (op)-1/bmp-7, and less efficiently bmp-4, bound to bmpr-ii. Bmpr-ii bound ligands only weakly alone, but the binding was facilitated by the presence of previously identified type i receptors for bmps. Binding of op-1/bmp-7 to bmpr-ii was also observed in nontransfected cell lines. Moreover, a transcriptional activation signal was transduced by bmpr-ii in the presence of type i receptors after stimulation by op-1/bmp-7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMPR2 | form complex 
binding
|
BMPR1A/1B/2 |
0.611 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-33443 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7791754 |
Using several complementary approaches, we investigated the formation of homomeric and heteromeric complexes between the two known bmp type i receptors (br-ia and br-ib) and the bmp type ii receptor (br-ii). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF1 | down-regulates
ubiquitination
|
BMPR2 |
0.542 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195654 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degradation of smads and receptors for tgf-beta and bmps. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153402 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17317136 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degradation of smads and receptors for tgf-beta and bmps. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
BMPR2 | up-regulates
binding
|
ACVR1 |
0.701 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-33434 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7791754 |
Bmpr-ii is a transmembrane serine/threonine kinase that binds bmp-2 and bmp-7 in association with multiple type i receptors, including bmpr-ia/brk1, bmpr-ib, and actr-i, which is also an activin type i receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF2 | down-regulates
ubiquitination
|
BMPR2 |
0.481 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-193119 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMPR1A | up-regulates
binding
|
BMPR2 |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75652 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10712517 |
Using several complementary approaches, we investigated the formation of homomeric and heteromeric complexes between the two known bmp type i receptors |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BMPR2 | up-regulates
phosphorylation, binding
|
BMPR1A |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180545 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18756288 |
Bmp ligands bind to the bmp receptors bmpr1 and bmpr2, and bmpr2 then phosphorylates and activates bmpr1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-33440 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 7791754 |
Bmpr-ii is a transmembrane serine/threonine kinase that binds bmp-2 and bmp-7 in association with multiple type i receptors, including bmpr-ia/brk1, bmpr-ib, and actr-i, which is also an activin type i receptor. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| + |
BMPR2 | up-regulates
binding, phosphorylation
|
BMPR1B |
0.608 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75655 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10712517 |
Using several complementary approaches, we investigated the formation of homomeric and heteromeric complexes between the two known bmp type i receptors (br-ia and br-ib) and the bmp type ii receptor (br-ii). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180548 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18756288 |
Bmp ligands bind to the bmp receptors bmpr1 and bmpr2, and bmpr2 then phosphorylates and activates bmpr1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
BMPR2 | up-regulates activity
binding
|
BMPR1B |
0.608 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219291 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 10712517 |
Using several complementary approaches, we investigated the formation of homomeric and heteromeric complexes between the two known bmp type i receptors (br-ia and br-ib) and the bmp type ii receptor (br-ii). |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
SMURF | down-regulates
ubiquitination
|
BMPR2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270215 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMPR2 | up-regulates activity
binding
|
BMPR1A |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255781 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10712517 |
Using several complementary approaches, we investigated the formation of homomeric and heteromeric complexes between the two known BMP type I receptors (BR-Ia and BR-Ib) and the BMP type II receptor (BR-II). Coimmunoprecipitation studies detected the formation of heteromeric and homomeric complexes among all the BMP receptor types even in the absence of ligand. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BMP2 | up-regulates
binding
|
BMPR2 |
0.793 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-33425 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7791754 |
Bmpr-ii is a transmembrane serine/threonine kinase that binds bmp-2 and bmp-7 in association with multiple type i receptors, including bmpr-ia/brk1, bmpr-ib, and actr-i, which is also an activin type i receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMPR2 | form complex
binding
|
ACVR1/BMPR2 |
0.701 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-33437 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7791754 |
Bmpr-ii is a transmembrane serine/threonine kinase that binds bmp-2 and bmp-7 in association with multiple type i receptors, including bmpr-ia/brk1, bmpr-ib, and actr-i, which is also an activin type i receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP15 | up-regulates
binding
|
BMPR2 |
0.553 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144098 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16446785 |
Here we have performed a detailed in situ hybridization analysis of the spatial and temporal expression patterns of the bmp ligands (bmp-2, -3, -3b, -4, -6, -7, -15), receptors (bmpr-ia, -ib, -ii), and bmp antagonist, follistatin, in rat ovaries over the normal estrous cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
BMP2 | up-regulates activity
binding
|
BMPR2 |
0.793 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144101 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 7791754 |
Under our assay conditions, bmp-2 binds better to bmpr-ii in combination with actr-i or bmpr-ib than in combination with bmpr-ia |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CTDNEP1 | down-regulates
binding
|
BMPR2 |
0.438 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151001 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17141153 |
We show that dullard promotes the ubiquitin-mediated proteosomal degradation of bmp receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
BMPR2
- 
- 