Summary

Name BMPR2
Full Name Bone morphogenetic protein receptor type-2
Synonyms BMP type-2 receptor, BMPR-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II | PPH1
Primary ID Q13873
Links - -
Type protein
Relations 23
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png binding BMPR2 0.40
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BMPR1A 0.98
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BMPR2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BMPR2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding, phosphorylation BMPR1A
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BMPR2
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates activity img/direct-activation.png binding BMPR2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding, phosphorylation BMPR1B
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BMPR2 0.36
Publications: 2 Organism: Gallus Gallus, Homo Sapiens
Tissue: Bone
+ up-regulates activity img/direct-activation.png binding BMPR1B 0.96
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding BMPR2 0.32
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates img/direct_inhibition.png ubiquitination BMPR2 0.37
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BMPR2 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BMPR2 0.66
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination BMPR2 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ACVR1 0.77
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding ACVR1/BMPR2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding BMPR1A/1B/2
Publications: 1 Organism: Homo Sapiens